达比加群酯

产品详情：

发布时间： 2024-07-15 12:33:37

CAS号：211915-06-9

常用名： 达比加群酯

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Dabigatran etexilate(BIBR-1048) is the orally active prodrug of dabigatran; Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.IC50 Value: 4.5 nM (Ki); 10 nM(Thrombin-induced platelet aggregation) [1]in vitro: Dabigatran selectively and reversibly inhibited human thrombin(Ki: 4.5 nM) as well as thrombin-induced platelet aggregation (IC(50): 10 nM), while showing no inhibitory effect on other platelet-stimulating agents.Thrombin generation in platelet-poor plasma (PPP), measured as the endogenous thrombin potential (ETP) was inhibited concentration-dependently (IC(50): 0.56 microM). Dabigatran demonstrated concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human PPP at concentrations of 0.23, 0.83 and 0.18 microM, respectively [1]. in vivo: Dabigatran prolonged the aPTT dose-dependently after intravenous administration in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg). Dose- and time-dependent anticoagulant effects were observed with dabigatran etexilate administered orally to conscious rats (10, 20 and 50 mg/kg) or rhesus monkeys (1, 2.5 or 5 mg/kg), with maximum effects observed between 30 and 120 min after administration, respectively [1]. Patients treated with dabigatran etexilate experienced fewer ischaemic strokes (3.74 dabigatran etexilate vs 3.97 warfarin) and fewer combined intracranial haemorrhages and haemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin) per 100 patient-years [2].Clinical trial: An Evaluation of the Pharmacokinetics and Pharmacodynamics of Oral Dabigatran Etexilate in Hemodialysis Patients . Phase1 物理化学性质： CAS号：211915-06-9 常用中文名：达比加群酯常用英文名：Dabigatran etexilate 分子式：C34H41N7O5 分子量：627.733 密度：1.2±0.1 g/cm3 沸点：827.9±75.0 °C at 760 mmHg 熔点：128-129° 闪点：454.5±37.1 °C 储存条件：2~8℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

邮件：sales@echemcloud.com

网址：http://www.echemcloud.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-07-15 价格：需询单达比加群酯

2017-06-24 价格：￥需询单达比加群酯

2018-02-19 价格：￥需询单达比加群酯

2017-10-19 价格：￥需询单达比加群酯

2021-02-06 价格：￥989.0 BIBR-1048

2017-06-18 价格：￥需询单达比加群酯杂质

2017-09-04 价格：￥需询单达比加群酯

2017-06-13 价格：￥需询单达比加群酯

2023-03-28 价格：￥111.0 达比加群酯

2017-12-01 价格：￥需询单达比加群酯

查看所有价格请点击：

达比加群酯价格

达比加群酯

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：