苯并二氧六环-6-(1-哌啶基)甲酰胺

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发布时间： 2024-07-15 12:33:40

CAS号：215923-54-9

常用名： 苯并二氧六环-6-(1-哌啶基)甲酰胺

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纯度： 99.0%

备货期： 10天

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用途： CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.IC50 value:Target: AMPAR agonistin vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation [2]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective [3]. in vivo: Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice [1]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) [4]. 物理化学性质： CAS号：215923-54-9 常用中文名：苯并二氧六环-6-(1-哌啶基)甲酰胺常用英文名：CX546 分子式：C14H17NO3 分子量：247.29000 密度：1.215g/cm3 沸点：422.8ºC at 760 mmHg 熔点：N/A 闪点：209.5ºC 储存条件：2-8℃

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2024-03-12 价格：￥747.9 CX 546

2021-02-06 价格：￥991.0 CX 546

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苯并二氧六环-6-(1-哌啶基)甲酰胺价格

苯并二氧六环-6-(1-哌啶基)甲酰胺

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