福沙那韦钙

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发布时间： 2024-07-15 12:33:54

CAS号：226700-81-8

常用名： 福沙那伟钙

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens; GW433908G is the calcium salt of the prodrug.IC50 Value:Target: HIV Proteasein vitro: There were no significant changes in buprenorphine or PI plasma levels and no significant changes in medication adverse effects or opioid withdrawal. Increased concentrations of the inactive metabolite buprenorphine-3-glucuronide suggested that darunavir-ritonavir and fosamprenavir-ritonavir induced glucuronidation of buprenorphine[1].in vivo: Fosamprenavir-ritonavir administered with methadone did not alter plasma amprenavir pharmacokinetics compared with historical control data; nor did it alter the unbound R-methadone at 2 and 6 hours after methadone dosing. Pharmacodynamic indexes remained essentially unchanged after adding fosamprenavir-ritonavir to methadone [2]. After a high-fat meal compared with fasting, (1) the bioavailability of GW433908G suspension was decreased by 20% and Cmax by 41%, and (2) for GW433908G tablets, there was no influence on AUC(12% lower Cmax). After a low-fat meal compared with fasting, (1) there was bioequivalence for GW433908G tablets, but (2) bioavailability was decreased by 23% for amprenavir capsules (Cmax was also lower, by 46%) [3].Clinical trial: Study of an Investigational Regimen Including FDA Approved HIV Drugs In HIV-Infected Pediatric Subjects. Phase 2 物理化学性质： CAS号：226700-81-8 常用中文名：福沙那伟钙常用英文名：Fosamprenavir (Calcium Salt) 分子式：C25H34CaN3O9PS 分子量：623.669 密度：N/A 沸点：N/A 熔点：282-284ºC 闪点：N/A 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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2024-07-15 价格：需询单福沙那韦钙

2023-11-18 价格：￥需询单 Fosamprenavir calcium

2021-02-06 价格：￥4489.0 Fosamprenavir Calcium Salt

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福沙那韦钙

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