4-(吡啶-4-基)-N-(间甲苯基)噻唑-2-胺

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更新时间： 2026-01-08 16:25:40

CAS号：315702-99-9

常用名： N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM in RCC4 and RCC4/VHL cells,respectively.It specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC.IC50: 0.625/16μM in RCC4 and RCC4/VHL cells,respectively.[1]In vitro: STF-62247 induces cytotoxicity in VHL-deficient cells in a HIF-independent manner, STF-62247 increases acidification in VHL-deficient cells ,TGN is a target of STF-62247 and a drug-selective pathway synthetically lethal in VHL-deficient cells.[1] Golgi trafficking are required as initial signals in STF-62247-induced autophagy.[2]STF-62247 increases radiosensitivity in a VHL-dependent manner.[3]In vivo: SN12C, SN12C-VHL shRNA, or 786-O cells were implanted subcutaneously into the flanks of immunodeficient mice. The selective cytotoxicity of STF-62247 for the VHL-deficient cells was also demonstrated in 786-O cells compared to their wild-type VHL counterparts by clonogenic assay in vitro. Daily treatment with STF-62247 significantly reduced tumor growth of VHL-deficient cells. This decrease in tumor growth was concentration dependent. Importantly, drug treatment did not have any effect on the growth of SN12C tumor cells that have wild-type VHL. Together,STF-62247 reduces tumor growth in VHL-deficient cells in mice.[1] 物理化学性质： CAS号：315702-99-9 常用中文名：N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺常用英文名：STF-62247 分子式：C15H13N3S 分子量：267.349 密度：1.3±0.1 g/cm3 沸点：444.8±47.0 °C at 760 mmHg 熔点：174.66° C 闪点：222.8±29.3 °C 储存条件：-20°C

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2022-02-19 价格：￥720.9 STF-62247

2023-02-25 价格：￥需询单 STF-62247

2023-09-25 价格：￥需询单 STF62247

2021-02-06 价格：￥519.0 STF-62247

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N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺价格

4-(吡啶-4-基)-N-(间甲苯基)噻唑-2-胺

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