BCTC

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发布时间： 2024-07-15 12:35:06

CAS号：393514-24-4

常用名： N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.Target: TRPM8in vitro: BCTC is a potent and specific antagonist of TRPM8, exerts an anti-tumor effect on the androgen-independent PCa DU145 cells, and the mechanism of how the inhibition functions. BCTC exerts an anti-proliferative effect on DU145 cells and induces tumor suppression through G0/G1 cell cycle arrest, and inhibition of migration and invasion. BCTC demonstrates excellent anti-tumor activity in PCa DU145 cells, and therefore has the potential to become a targeted therapeutic strategy against PCa. [1]in vivo: BCTC is a potent, selective, and orally bioavailable antagonist of rat VR1. BCTC not only blocks the activation of rat VR1 by capsaicin but also by low pH at the native rat VR1 in a skin-nerve preparation. Thus, BCTC has provided us with an opportunity to test our hypothesis that the inhibition of low pH induced activation of VR1 confers in vivo efficacy in models of chronic pain. This report describes the effects of BCTC in models of inflammatory, neuropathic, and capsaicin-induced pain in the rat. The efficacy and side effect profile of BCTC in these models were compared with those of nonsteroidal anti-inflammatory drugs and antiepileptic drugs currently used for the clinical therapy of inflammatory and neuropathic pain, respectively.[2] 物理化学性质： CAS号：393514-24-4 常用中文名：N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺常用英文名：BCTC 分子式：C20H25ClN4O 分子量：372.892 密度：1.2±0.1 g/cm3 沸点：561.6±50.0 °C at 760 mmHg 熔点：N/A 闪点：293.4±30.1 °C 储存条件：2-8℃

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2022-02-19 价格：￥568.9 BCTC

2024-07-15 价格：需询单 BCTC

2021-02-06 价格：￥789.0 BCTC

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N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺价格

BCTC

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