Pamapimod
产品详情：
发布时间： 2024-07-15 12:35:20
CAS号：449811-01-2
常用名：
价格：
纯度： 98.0%
备货期： 10天
库存： 现货
其他详情（用途，包装）：
用途： Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. Pamapimod is p38 inhibitor with IC50 of 0.06μM in THP-1 cell.IC50: 0.014 ± 0.002 and 0.48 ± 0.04 μM(p38α and p38β enzymatic activity,respectively.)IC50:0.06μM (THP-1 cell)[1]In vitro: Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. There was no activity against p38δ or p38γ isoforms. When profiled across 350 kinases, pamapimod bound only to four kinases in addition to p38. Cellular potency was assessed using phosphorylation of heat shock protein-27 and c-Jun as selective readouts for p38 and c-Jun NH2-terminal kinase (JNK), respectively. Pamapimod inhibited p38 (IC50, 0.06 μM), but inhibition of JNK was not detected.Pamapimod also inhibited lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production by monocytes, interleukin (IL)-1β production in human whole blood, and spontaneous TNFα production by synovial explants from RA patients. LPS- and TNFα-stimulated production of TNFα and IL-6 in rodents also was inhibited by pamapimod. [1]In vivo: In murine collagen-induced arthritis, pamapimod reduced clinical signs of inflammation and bone loss at 50 mg/kg or greater. In a rat model of hyperalgesia, pamapimod increased tolerance to pressure in a dose-dependent manner, suggesting an important role of p38 in pain associated with inflammation. Finally, an analog of pamapimod that has equivalent potency and selectivity inhibited renal disease in lupus-prone MRL/lpr mice. [1] 物理化学性质： CAS号：449811-01-2 常用中文名：Pamapimod 常用英文名：Pamapimod 分子式：C19H20F2N4O4 分子量：406.38300 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20℃
供应商信息：
公司名：上海念兴实业有限公司 推荐
认证状态： 已认证供应商
商品数： 403768件
电话： 18916513247
地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市普陀区
联系人： 小陈
联系人电话： 0086-021-52280163
邮件：sales@echemcloud.com
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推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：
公司名：武汉敬康恩生物医药科技有限公司
区域：武汉市东西湖区
价格：
￥需询单/1g
联系人：周经理
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2024-07-15 价格：需询单
2023-11-18 价格：￥需询单
2023-09-25 价格：￥需询单
2021-02-06 价格：￥4065.0
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Pamapimod价格为, 由Pamapimod生产厂家上海念兴实业有限公司提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：Pamapimod_价格_生产厂家【上海念兴实业有限公司】
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