沙蟾毒精

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发布时间： 2024-07-15 12:35:22

CAS号：464-74-4

常用名： 沙蟾蜍精

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.IC50 value: Target: in vitro: arenobufagin induced mitochondria-mediated apoptosis in HCC cells, with decreasing mitochondrial potential, as well as increasing Bax/Bcl-2 expression ratio, Bax translocation from cytosol to mitochondria. Arenobufagin also induced autophagy in HepG2/ADM cells. Autophagy-specific inhibitors (3-methyladenine, chloroquine and bafilomycin A1) or Beclin1 and Atg 5 small interfering RNAs (siRNAs) enhanced arenobufagin-induced apoptosis, indicating that arenobufagin-mediated autophagy may protect HepG2/ADM cells from undergoing apoptotic cell death [1]. arenobufagin inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in vitro [2]. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1 [3].in vivo: arenobufagin inhibited the growth of HepG2/ADM xenograft tumors, which were associated with poly (ADP-ribose) polymerase cleavage, light chain 3-II activation and mTOR inhibition [1]. Arenobufagin also suppressed sprouting formation from VEGF-treated aortic rings in an ex vivo model [2]. 物理化学性质： CAS号：464-74-4 常用中文名：沙蟾蜍精常用英文名：Arenobufagin 分子式：C24H32O6 分子量：416.507 密度：1.4±0.1 g/cm3 沸点：637.2±55.0 °C at 760 mmHg 熔点：N/A 闪点：219.3±25.0 °C 储存条件：-20°C

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公司名：上海念兴实业有限公司推荐

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2025-12-29 价格：￥需询单沙蟾毒精

2021-04-03 价格：￥762.0 Arenobufagin

2022-10-11 价格：￥750.0 沙蟾蜍精，沙蟾毒精Arenobufagin

2024-09-29 价格：￥需询单沙蟾毒精

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沙蟾毒精

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