CP-809101?

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发布时间： 2024-07-15 12:35:25

CAS号：479683-64-2

常用名： 6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. IC50 Value: 9.96(pEC50 for 5-HT2C); 7.19(pEC50 for 5-HT2B); 6.81(pEC50 for 5-HT2A)Target: 5-HT2C ReceptorCP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro. The aim of the present studies was to assess the efficacy of a selective 5-HT2C agonist in animal models predictive of antipsychotic-like efficacy and side-effect liability. Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT2C agonist, CP-809101, has a pharmacological profile similar to that of the atypical antipsychotics with low extrapyramidal symptom liability. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test and learned helplessness. 物理化学性质： CAS号：479683-64-2 常用中文名：6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪常用英文名：CP-809101 分子式：C15H17ClN4O 分子量：304.77 密度：1.3±0.1 g/cm3 沸点：486.6±45.0 °C at 760 mmHg 熔点：N/A 闪点：248.1±28.7 °C 储存条件：2-8℃

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2022-03-04 价格：￥4150.0 CP-809101

2021-02-06 价格：￥5349.0 CP-809101

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6'-(3-氯苄基氧基)-3,4,5,6-四氢-2H-[1,2']联吡嗪价格

CP-809101?

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