Pentamidine dihydrochloride

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发布时间： 2024-07-15 12:35:29

CAS号：50357-45-4

常用名： 喷他脒二盐酸盐

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Pentamidine Dihydrochloride(MP601205 dihydrochloride) is an antimicrobial agent.Target: AntiparasiticPentamidine Dihydrochloride has a potent in vitro antiprotozoal activity. Pentamidine displays cytotoxic activity against L. infantum promastigotes with IC50 of 2.5 μM. 2.5 μM Pentamidine induces early programmed cell death in 49.6% of L. infantum promastigotes. 2.5 μM Pentamidine induces a notorious decrease in promastigotes in both G1 and S phases relative to the control-untreated samples (G1:77.0 vs 15.0%; S:11.0 vs 2.4% for control- and pentamidine-treated promastigotes, resp). Pentamidine is able to bind with calf-thymus DNA (CT-DNA) and induces conformational changes in the DNA double helix. Pentamidine also binds with ubiquitin to modifiy the β-cluster of ubiquitin [1]. Pentamidine is an inhibitor of phosphatase of regenerating liver (PRLs). 1 μg/mL of Pentamidine complete inhibits the activity of recombinant PTP1B in dephosphorylating a phos-photyrosine peptide. 10 μg/mL of Pentamidine completely inhibits the activities of recombinant PRL-1, PRL-2 and PRL-3 in dephosphorylating a phosphotyrosine peptide substrate. Incubation with Pentamidine (1 μg/mL) for 48 h reduces the activity of intracellular PRL phosphatases in transfected NIH3T3 cells by more than 85%. 10 μg/mL Pentamidine completely inhibits the growth of melanoma cell line (WM9), prostate carcinoma cell line (DU145 and C4-2), ovarian carcinoma cell line (Hey), colon carcinoma cell line (WM480), and lung carcinoma cell line (A549) which all express endogenous PRLs [2]. 物理化学性质： CAS号：50357-45-4 常用中文名：喷他脒二盐酸盐常用英文名：Pentamidine dihydrochloride 分子式：C19H26Cl2N4O2 分子量：413.34 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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2024-07-15 价格：需询单 Pentamidine dihydrochloride

2022-11-29 价格：￥需询单 Pentamidine dihydrochloride

2021-02-06 价格：￥869.0 Pentamidine dihydrochloride

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喷他脒二盐酸盐价格

Pentamidine dihydrochloride

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