醋酸氟卡尼

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更新时间： 2026-01-03 11:13:56

CAS号：54143-56-5

常用名： 醋酸氟卡胺

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.IC50 Value:Target: Nav1.5 channelFlecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.in vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation threshold, being greater at -90 mV as compared to -120 and -180 mV [2].in vivo: Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2 [3].Clinical trial: To Evaluate the Impact of Oral Flecainide on Quality of Life in Patients With Paroxysmal Atrial Fibrillation . Phase4 物理化学性质： CAS号：54143-56-5 常用中文名：醋酸氟卡胺常用英文名：flecainide acetate 分子式：C19H24F6N2O5 分子量：474.395 密度：1.286g/cm3 沸点：434.9ºC at 760mmHg 熔点：145-147℃ 闪点：216.8ºC 储存条件：2-8°C

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公司名：上海念兴实业有限公司推荐

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2025-09-17 价格：￥需询单 N-(哌啶-2-基甲基)-2,5-双(2,2,2-三氟乙氧基)苯甲酰胺乙酸盐

2021-02-06 价格：￥1749.0 Flecainide acetate

2017-12-08 价格：￥需询单醋酸氟卡胺

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醋酸氟卡尼

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