4-甲基-2-(1-哌啶基)喹啉

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发布时间： 2024-07-15 12:35:43

CAS号：5465-86-1

常用名： ML204

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.IC50 value:Target: TRPC4/C5 inhibitorML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. In whole-cell patch clamp recordings, ML204 blocked TRPC4β currents activated through either μ-opioid receptor stimulation or intracellular dialysis of guanosine 5'-3-O-(thio)triphosphate (GTPγS), suggesting a direct interaction of ML204 with TRPC4 channels rather than any interference with the signal transduction pathways. Selectivity studies showed no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons. In isolated guinea pig ileal myocytes, ML204 blocked muscarinic cation currents activated by bath application of carbachol or intracellular infusion of GTPγS, demonstrating its effectiveness on native TRPC4 currents [1]. ML204 blocked TRPC4 channels in an electrophysiological assay with an IC value of 2.6 μM and was also active in fluorescent and electrophysiological assays in which TRPC4 channels were activated by different mechanisms, indicating direct block of TRPC4 channels. Selectivity for block of TRPC4 channels was examined in fluorescent and electrophysiological experiments against closely related TRPC channels and more distantly related TRPV, TRPA and TRPM channels, and against non-TRP ion channels. ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels [2]. 物理化学性质： CAS号：5465-86-1 常用中文名：ML204 常用英文名：ML204 分子式：C15H18N2 分子量：226.317 密度：1.1±0.1 g/cm3 沸点：404.4±33.0 °C at 760 mmHg 熔点：N/A 闪点：198.4±25.4 °C 储存条件：-20℃

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公司名：上海念兴实业有限公司推荐

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2024-03-12 价格：￥490.9 4-甲基-2-(1-哌啶基)-喹啉

2025-09-17 价格：￥需询单 4-甲基-2-(1-哌啶基)喹啉

2021-02-06 价格：￥913.0 ML 204

2021-05-10 价格：￥需询单 4-METHYL-2-(1-PIPERIDINYL)-QUINOLINE

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4-甲基-2-(1-哌啶基)喹啉

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