木香烃内酯

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更新时间： 2026-01-11 07:46:20

CAS号：553-21-9

常用名： 木香烃内酯

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.IC50 Value: 6.2 - 9.8 ug/mL(sarcoma cells viability)[3]Target: Apoptosis inducerin vitro: Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and its downstream target PARP [2]. Both costunolide and dehydrocostus lactone inhibited cell viability dose- and time-dependently. IC50 values ranged from 6.2 ug/mL to 9.8 ug/mL. Cells treated with costunolide showed no changes in cell cycle, little in caspase 3/7 activity, and low levels of cleaved caspase-3 after 24 and 48 h [3].in vivo: Neither costunolide nor alpha-MGBL affected the blood-ethanol elevation in pylorus-ligated rats or that induced by intraperitoneal and intraduodenal ethanol administration [4]. Costunolide and alpha-MGBL suppressed gastric emptying in rats given 20% ethanol and 1% sodium carboxymethyl cellulose.Clinical trial: 物理化学性质： CAS号：553-21-9 常用中文名：木香烃内酯常用英文名：Costunolide 分子式：C15H20O2 分子量：232.318 密度：1.0±0.1 g/cm3 沸点：385.4±42.0 °C at 760 mmHg 熔点：106 °C 闪点：162.0±25.3 °C 储存条件：Store at -20°C

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公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

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2024-09-29 价格：￥需询单木香烃内酯

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2016-03-11 价格：￥280.0 木香烃内酯

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2024-05-16 价格：￥需询单木香烃内酯

2021-02-06 价格：￥829.0 Costunolide

2017-10-04 价格：￥需询单木香烃内酯

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木香烃内酯

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