4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮

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发布时间： 2024-07-15 12:36:10

CAS号：64224-21-1

常用名： 吡噻硫酮

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Oltipraz has an inhibitory effect on HIF-1α activation by insulin in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.IC50 value: 10 μMTarget: HIF-1αin vitro: Oltipraz inhibits HIF-1α activity and HIF-1α-dependent tumor growth, which may result from a decrease in HIF-1α stability through S6K1 inhibition in combination with an H2O2-scavenging effect. Oltipraz treatment also inhibits HIF-1α activation stimulated by either hypoxia or CoCl2. Oltipraz is a cancer chemopreventive agent and has an inhibitory effect on angiogenesis and tumor growth. [1] Oltipraz is also a competitive inhibitor of this cytochrome P450, with an apparent Ki of 10 μM. [2]in vivo: In wild-type mice, hepatic levels of mRNA for all of the genes analyzed were significantly increased after Oltipraz treatment, with the highest increase (treated/control) for NQO1 mRNA levels (7.6-fold). The Northern blot analyses demonstrated that the observed increases in GST and NQO1 activities by Oltipraz in wild-type mice were preceded by significant elevations in RNA expression. Interestingly, mRNA levels of Nrf2 itself were increased more than 3-fold by Oltipraz treatment. [2] 物理化学性质： CAS号：64224-21-1 常用中文名：吡噻硫酮常用英文名：Oltipraz 分子式：C8H6N2S3 分子量：226.342 密度：1.5±0.1 g/cm3 沸点：408.1±55.0 °C at 760 mmHg 熔点：165-166ºC 闪点：200.6±31.5 °C 储存条件：2-8°C

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2022-02-19 价格：￥179.9 Oltipraz

2019-03-05 价格：￥1116.0 吡噻硫酮

2025-09-17 价格：￥需询单 4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮

2024-07-15 价格：需询单 4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮

2020-12-08 价格：￥889.0 吡噻硫酮

2021-05-10 价格：￥需询单吡噻硫酮

2024-01-09 价格：$需询单 OLTIPRAZ

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吡噻硫酮价格

4-甲基-5-(吡嗪-2-基)-3H-1,2-二硫-3-硫酮

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