1-(2-(苯甲基氧基)乙基)-4-(3-苯丙基)哌嗪二盐酸盐

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发布时间： 2024-07-15 12:36:17

CAS号：67469-81-2

常用名： GBR 12935二盐酸盐

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor.IC50 value: Target: dopamine reuptake inhibitorin vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6. The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine) [1]. Co-perfusion of 100 microM GBR 12909 or GBR 12935 with either 100 microM sulpiride or raclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopamine to basal levels. In vitro, GBR 12909 (1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens [2].in vivo: GBR 12935 elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg. Locomotor stimulation by GBR 12935 remained consistent in both strains with repeated injections. DBA/2J mice became sensitized to cocaine-induced stereotypy with repeated injections. Cocaine induced no stereotypy in C57BL/6J mice on any test day. No stereotypies were induced by GBR 12935 in either strain on any test day [3]. 物理化学性质： CAS号：67469-81-2 常用中文名：GBR 12935二盐酸盐常用英文名：GBR 12935 dihydrochloride 分子式：C28H36Cl2N2O 分子量：487.504 密度：N/A 沸点：564ºC at 760 mmHg 熔点：N/A 闪点：294.9ºC 储存条件：-20℃

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2024-07-15 价格：需询单 1-(2-(苯甲基氧基)乙基)-4-(3-苯丙基)哌嗪二盐酸盐

2022-03-04 价格：￥308.9 GBR 12935 dihydrochloride

2021-02-06 价格：￥1229.0 GBR 12935 dihydrochloride

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GBR 12935二盐酸盐价格

1-(2-(苯甲基氧基)乙基)-4-(3-苯丙基)哌嗪二盐酸盐

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