Zonisamide sodium

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发布时间： 2024-07-15 12:36:19

CAS号：68291-98-5

常用名： 唑尼沙胺钠

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.Target: Calcium channel inhibitor; Sodium channel inhibitorZonisamide sodium is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure. Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug. It has shown activity in various animal models of epilepsy, and although a detailed mode of action awaits clarification it appears to block the propagation/spread of seizure discharges and to suppress the epileptogenic focus [1].Zonisamide sodium 500 mg/day was significantly superior to placebo in reducing the frequency of complex partial seizures (-51% versus -16%), all partial seizures and all seizures, with dose-dependent benefit provided over a 100-500 mg/day dose range. Supporting trials have confirmed significant increases in reduction in median seizure frequency (up to 41%) and responder rates (35-42%) compared with placebo following zonisamide sodium 400-600 mg/day, enabling 20-27% of patients to attain >or=75% reduction in seizure frequency [2].Clinical indications: Epilepsy; Lewy body dementia; Parkinsons diseaseToxicity: Anorexia; Somnolence; Dizziness; Irritability; Confusional state; Depression; Diplopia; Memory impairment 物理化学性质： CAS号：68291-98-5 常用中文名：唑尼沙胺钠常用英文名：Zonisamide sodium 分子式：C8H7N2NaO3S 分子量：234.208 密度：N/A 沸点：457.2ºC at 760 mmHg 熔点：N/A 闪点：N/A 储存条件：2-8℃

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2022-03-04 价格：￥5199.9 唑尼沙胺钠盐

2024-07-15 价格：需询单 Zonisamide sodium

2021-02-06 价格：￥1279.0 Zonisamide sodium

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Zonisamide sodium

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