1,1'-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲)

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发布时间： 2024-07-15 12:36:27

CAS号：711019-86-2

常用名： N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors.IC50 value: 37 nM [1]Target: P2Y6 receptorin vitro: MRS2578 selectively blocks P2Y6 receptor activity versus activity at P2Y1, P2Y2, P2Y4 or P2Y11 receptors. MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFalpha-induced apoptosis in 1321N1 astrocytoma cells [1]. MRS 2578 inhibits basal NF-κB activity in time and dose dependent manner in HMEC-1 cells transfected with 0.25 μg NF-κB promoter reporter. MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells [2]. MRS2578-treated mice shows reduced bronchial hyperresponsiveness toward methacholine in OVA-sensitized mice. MRS2578 completely blocks UDP-induced the release of IL-6, KC, and IL-8 in lung epithelial cells [3]. in vivo: MRS 2578 (10 μM) attenuates Keratinocyte-derived chemokine serum protein levels in LPS-induced vascular inflammation in C57BL/6 mice [2]. MRS2578 (10 μM, intratracheally) reduces BALF eosinophilia and the levels of IL-5 and IL-13 in the BALF in OVA-sensitized mice and leads to a markedly attenuated change in methacholine responsiveness after OVA challenge. MRS2578 (10 μM, intratracheally) inhibits house dust mite–induced allergic airway inflammation in OVA-sensitized mice. MRS2578 (10 μM, intratracheally) reduces of IL-6 and KC levels in BALF in OVA-sensitized mice [4]. 物理化学性质： CAS号：711019-86-2 常用中文名：N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲常用英文名：MRS 2578 分子式：C20H20N6S4 分子量：472.673 密度：1.3±0.1 g/cm3 沸点：652.7±65.0 °C at 760 mmHg 熔点：N/A 闪点：348.5±34.3 °C 储存条件：2-8°C

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公司名：上海念兴实业有限公司推荐

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2022-11-29 价格：￥需询单 MRS 2578

2021-02-06 价格：￥489.0 MRS 2578

2022-02-19 价格：￥468.9 MRS 2578

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N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲价格

1,1'-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲)

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