BAY 61-3606

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更新时间： 2026-02-16 09:27:34

CAS号：732983-37-8

常用名： Syk抑制剂IV,BAY 61-3606 HCl

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.IC50 value: 7.5 nM (Ki) [1]Target: Sykin vitro: BAY 61-3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61-3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8.1 nM). B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes were also potently suppressed by BAY 61-3606 [1]. We identified BAY61-3606 as an inhibitor of proliferation in colorectal cancer cells expressing mutant forms of K-RAS, but not in isogenic cells expressing wild-type K-RAS. In addition to its anti-proliferative effects in mutant cells, BAY61-3606 exhibited a distinct biological property in wild-type cells in that it conferred sensitivity to inhibition of RAF. In this context, BAY61-3606 acted by inhibiting MAP4K2 (GCK), which normally activates NFκβ signaling in wild-type cells in response to inhibition of RAF [2].in vivo: Oral administration of BAY 61-3606 to rats significantly suppressed antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema at 3 mg/kg. Furthermore, BAY 61-3606 attenuated antigen-induced airway inflammation in rats [1]. 物理化学性质： CAS号：732983-37-8 常用中文名：Syk抑制剂IV,BAY 61-3606 HCl 常用英文名：BAY 61-3606 分子式：C20H18N6O3 分子量：390.395 密度：1.4±0.1 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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地区： 上海市普陀区

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2022-03-04 价格：￥1110.0 Syk抑制剂IV，BAY 61-3606 HCl

2024-07-15 价格：需询单 BAY 61-3606

2023-09-27 价格：￥需询单 BAY61-3606

2021-02-06 价格：￥4689.0 BAY 61-3606

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Syk抑制剂IV,BAY 61-3606 HCl价格

BAY 61-3606

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