20-HETE

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发布时间： 2024-07-15 12:36:51

CAS号：79551-86-3

常用名： 20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： 20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels.IC50 Value:Target: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension. in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2].in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice had overexpressed hepatic CYP4F2, high hepatic 20-HETE and fasting plasma glucose levels but normal insulin level. The GP activity was increased and the cAMP/PKA-PhK-GP pathway was activated in the transgenic mice compared with wild-type mice [5]. Clinical trial: Mechanisms of Response to Diesel Exhaust in Subjects With Asthma. Phase not specified 物理化学性质： CAS号：79551-86-3 常用中文名：20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸常用英文名：20-HETE 分子式：C20H32O3 分子量：320.47 密度：1.0±0.1 g/cm3 沸点：482.0±33.0 °C at 760 mmHg 熔点：N/A 闪点：259.4±21.9 °C 储存条件：−20°C

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2024-07-15 价格：需询单 20-HETE

2021-04-03 价格：￥需询单 20-HETE

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20-HETE

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