维司力农

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发布时间： 2024-07-15 12:36:55

CAS号：81840-15-5

常用名： 维司力农

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.IC50 value: 1.1 μM (for HERG current)Target: PDE3in vitro: HERG current is inhibited by Vesnarinone with an IC50 of 1.1 μM, whereas KvLQT1/minK current is not significantly depressed by Vesnarinone even at 30 μM. The IC50 value for Vesnarinone inhibition of HERG channels is 1 μM. The IC50 for Vesnarinone inhibition of PDE is reported to be 300 μM. [1] Vesnarinone is a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. Vesnarinone inhibits BLM-induced pulmonary fibrosis, at least in part, by the inhibition of acute lung injuries in the early phase. [2] Vesnarinone is a new and novel inotropic drug that has unique and complex mechanisms of action. Vesnarinone inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. Vesnarinone has also demonstrated significant effects on cytokine production, which may account for some of its observed clinical benefits.[3] Vesnarinone plays an important role in the regulation of cytokines and suggest that the reduction of cytokine release may contribute to the beneficial effects of the drug in the treatment of heart failure. Vesnarinone inhibits the production of TFN-a and IFN-y by LPS stimulated whole blood from patients with heart failure and from healthy volunteers. [4]in vivo: Vesnarinone reduces the circulating levels of TNF-α. Cumulative evidence showed that a variety of cytokine are involved in the pathogenesis of pulmonary fibrosis. [2] 物理化学性质： CAS号：81840-15-5 常用中文名：维司力农常用英文名：Vesnarinone 分子式：C22H25N3O4 分子量：395.45200 密度：1.246g/cm3 沸点：678.3ºC at 760 mmHg 熔点：238.1-239.5° (Tominaga); mp 238.1-239.8° (Shimizu) 闪点：364ºC 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

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2025-02-05 价格：￥5000.9 Vesnarinone

2024-07-15 价格：需询单维司力农

2021-04-03 价格：￥2800.0 Vesnarinone

2022-05-12 价格：$需询单 VESNARINONE

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