拉莫三嗪

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发布时间： 2024-07-15 12:36:59

CAS号：84057-84-1

常用名： 拉莫三嗪

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated [4]. 物理化学性质： CAS号：84057-84-1 常用中文名：拉莫三嗪常用英文名：lamotrigine 分子式：C9H7Cl2N5 分子量：256.091 密度：1.6±0.1 g/cm3 沸点：503.1±60.0 °C at 760 mmHg 熔点：177-181°C 闪点：258.1±32.9 °C 储存条件：2-8°C

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2022-02-19 价格：￥572.9 拉莫三嗪

2017-08-03 价格：￥需询单拉莫三嗪

2020-12-08 价格：￥880.0 拉莫三嗪

2024-05-13 价格：￥需询单拉莫三嗪

2024-01-09 价格：$需询单 Lamotrigine

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