O-Pyruvoylsalicylicacidhydrate

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发布时间： 2024-07-15 12:37:06

CAS号：856095-68-6

常用名： OBA-09

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： OBA-09 is a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester); shows robust protective effects in the postischemic brain.IC50 value:Target: OBA-09 exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. Reactive oxygen species generation was markedly suppressed in primary cortical cultures under oxygen-glucose deprivation. More interestingly, OBA-09 was capable of scavenging hydroxyl radical in cell-free assays. High-performance liquid chromatography results demonstrated that OBA-09 was hydrolyzed to salicylic acid and pyruvate with t1/2 = 43 min in serum and 4.2 h in brain parenchyma, indicating that antioxidative function of OBA-09 is executed by itself and also by salicylic acid after the hydrolysis. In addition to antioxidative function, OBA-09 exerts anti-excitotoxic and anti-Zn2+-toxic functions, which might be attributed to attenuation of ATP and nicotinamide adenine dinucleotide depletion and to the suppression of nuclear factor-κB activity induction. Together these results indicate that OBA-09 has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain and these effects were conferred by OBA-09 itself and subsequently its hydrolyzed products. 物理化学性质： CAS号：856095-68-6 常用中文名：OBA-09 常用英文名：OBA-09 分子式：C10H8O5 分子量：208.16800 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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2024-07-15 价格：需询单 O-Pyruvoylsalicylicacidhydrate

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O-Pyruvoylsalicylicacidhydrate

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