沃诺拉赞

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发布时间： 2024-07-15 12:37:18

CAS号：881681-00-1

常用名： 沃诺拉赞

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： TAK-438 (free base) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+ ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.IC50 value: 19 nM [1]Target: H+/K+ ATPasein vitro: TAK-438 is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date. TAK-438 inhibits gastric H+/K+ ATPase activity in a concentration-dependent manner. Under neutral conditions (pH 7.5), the inhibitory activity of TAK-438 is almost the same as that under weakly acidic conditions (pH 6.5). TAK-438 does not inhibit Na+/K+ ATPase activity even at concentration 500 times higher than their IC50 values against gastric H+/K+ ATPase activity. TAK-438 inhibits gastric H+/K+ ATPase in a K+ competitive manner with Ki of 3 nM [2]. in vivo: TAK-438 inhibits basal gastric acid secretion in a dose-dependent manner, and the ID50 value is 1.26 mg/kg. Intravenous administration of TAK-438 dose-dependently increases the pH of the gastric perfusate, and the increase in pH is sustained for 5 h after administration. At the 1 mg/kg dose, the pH plateaues 90 min after administration, and the highest pH value reached is 5.9 [2]. In addition, TAK-438 shows a potent and longer-lasting inhibitory effect on the histamine-stimulated gastric acid secretion in rats and dogs. TAK-438 shows significant antisecretory activity through high accumulation and slow clearance from the gastric tissue. TAK-438 is unaffected by the gastric secretory state, unlike PPIs [3]. 物理化学性质： CAS号：881681-00-1 常用中文名：沃诺拉赞常用英文名：Vonoprazan 分子式：C17H16FN3O2S 分子量：345.391 密度：1.3±0.1 g/cm3 沸点：530.3±60.0 °C at 760 mmHg 熔点：N/A 闪点：274.5±32.9 °C

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

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网址：http://www.echemcloud.com

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其他供应商价格：

2022-11-04 价格：￥需询单沃诺拉赞/伏诺拉生

2025-02-05 价格：￥1649.9 沃诺拉赞

2024-07-15 价格：需询单沃诺拉赞

2025-09-17 价格：￥需询单沃诺拉赞

2019-03-05 价格：￥506.0 沃诺拉赞

2017-06-12 价格：￥需询单凡诺帕胺

2022-05-12 价格：$需询单 Vonoprazan

2021-10-18 价格：￥100.0 沃诺拉赞 (Vonoprazan)

2024-01-09 价格：$需询单 Vonoprazan

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沃诺拉赞

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