7,9-二甲基-6-(5-甲基呋喃-2-基)-11-苯基-5,6-二氢嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(7H,9H)-二酮

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发布时间： 2024-07-15 12:37:47

CAS号：931706-15-9

常用名： PPQ-102

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC50 of ~90 nM. IC50 value: 90 nM [1]Target: CFTRin vitro: The most potent compound, 7,9-dimethyl-11-phenyl-6-(5-methylfuran-2-yl)-5,6-dihydro-pyrimido[4',5'-3,4]pyrrolo[1,2-a]quinoxaline-8,10-(7H,9H)-dione, PPQ-102, completely inhibited CFTR chloride current with IC(50) approximately 90 nM. The PPQs, unlike prior CFTR inhibitors, are uncharged at physiological pH, and therefore not subject to membrane potential-dependent cellular partitioning or block efficiency. Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state [1]. The three gpSlc26 anion transporters exhibited distinct pharmacological profiles of (36)Cl(-) influx, including partial sensitivity to CFTR inhibitors Inh-172 and GlyH101, but only Slc26a11 was inhibited by PPQ-102 [2]. Airway epithelial NCI-H292 cells and primary cultures of noncystic fibrosis human airway epithelial cells were treated with cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors (CFTR-inh(172) or PPQ-102) or transfected with a CFTR small interfering (si)RNA with or without a selective epidermal growth factor receptor tyrosine kinase inhibitor [3].in vivo: PPQ-102 prevented cyst expansion and reduced the size of preformed cysts in a neonatal kidney organ culture model of polycystic kidney disease. PPQ-102 is the most potent CFTR inhibitor identified to date [1]. 物理化学性质： CAS号：931706-15-9 常用中文名：PPQ-102 常用英文名：PPQ 102 分子式：C26H22N4O3 分子量：438.478 密度：1.4±0.1 g/cm3 沸点：648.7±65.0 °C at 760 mmHg 熔点：N/A 闪点：346.1±34.3 °C 储存条件：-20℃

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2022-03-04 价格：￥1289.9 PPQ 102

2021-02-06 价格：￥1069.0 PPQ-102

2023-09-11 价格：￥需询单 PPQ-102

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PPQ-102价格

7,9-二甲基-6-(5-甲基呋喃-2-基)-11-苯基-5,6-二氢嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(7H,9H)-二酮

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