1-NaphthylPP1(hydrochloride)

产品详情：

发布时间： 2024-07-15 12:37:58

CAS号：956025-47-1

常用名： 1-萘基PP1盐酸盐

价格：

纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： 1-Naphthyl PP1(1-NA-PP1) hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).IC50 Value:1.0 uM (v-Src); 0.6 uM (c-Fyn); 18 uM (c-Abl) [1]Target: Src Family kinase1-NA-PP1 was considerably more potent and showed distinct substituent effects at the pyrazolopyrimidine core. 1-NA-PP1 was cell-active, and potently blocked prostate cancer cell proliferation by inducing G2/M arrest. Overexpression of PKD1 or PKD3 almost completely reversed the growth arrest and the inhibition of tumor cell invasion caused by 1-NA-PP1, indicating that its anti-proliferative and anti-invasive activities were mediated through the inhibition of PKD. Interestingly, a 12-fold increase in sensitivity to 1-NA-PP1 could be achieved by engineering a gatekeeper mutation in the active site of PKD1, suggesting that 1-NA-PP1 could be paired with the analog-sensitive PKD1(M659G) for dissecting PKD-specific functions and signaling pathways in various biological systems [2]. 物理化学性质： CAS号：956025-47-1 常用中文名：1-萘基PP1盐酸盐常用英文名：1-Naphthyl PP1 (hydrochloride) 分子式：C19H20ClN5 分子量：353.84900 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

商品数： 403768件

电话： 18916513247

地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai

地区： 上海市普陀区

联系人： 小陈

联系人电话： 0086-021-52280163

邮件：sales@echemcloud.com

网址：http://www.echemcloud.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：

其他供应商价格：

2024-07-15 价格：需询单 1-NaphthylPP1(hydrochloride)

2022-11-29 价格：￥需询单 1-NA-PP 1 hydrochloride

2022-09-23 价格：￥1009.0 1-Naphthyl PP1 hydrochloride

2025-02-05 价格：￥4100.9 1-Naphthyl PP1 hydrochloride

查看所有价格请点击：

1-萘基PP1盐酸盐价格

1-NaphthylPP1(hydrochloride)

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：