A-836339
产品详情：
发布时间： 2024-07-15 12:38:00
CAS号：959746-77-1
常用名：
价格：
纯度： 99.0%
备货期： 10天
库存： 现货
其他详情（用途，包装）：
用途： A-836339 is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors.IC50 value: 1.6 nM(EC50) [1]Target: CB2 agonistin vitro: In radioligand binding assays, A-836339 displays high affinities at CB(2) receptors and selectivity over CB(1) receptors in both human and rat.In addition A-836339 exhibits a profile devoid of significant affinity at other G-protein-coupled receptors and ion channels [1].in vivo: In the complete Freund's adjuvant model of inflammatory pain, A-836339 exhibits a potent CB(2) receptor-mediated antihyperalgesic effect that is independent of CB(1) or mu-opioid receptors. A-836339 has also demonstrated efficacies in the chronic constrain injury (CCI) model of neuropathic pain, skin incision, and capsaicin-induced secondary mechanical hyperalgesia models [1]. Similar to systemic delivery, intra-spinal injection of A-836339 (0.3 and 1 nmol) also attenuated both von Frey-evoked and spontaneous firing of WDR neurons in neuropathic rats. Intra-spinal injections of A-836339 were ineffective in sham rats [2]. Systemic A-836339 and AM1241 produced dose-dependent efficacy in both inflammatory and neuropathic pain models. Local administration of CB? agonists also produced significant analgesic effects in SNL (intra-DRG and i.t.) and CFA (intra-DRG) pain models [3]. 物理化学性质： CAS号：959746-77-1 常用中文名：A-836339 常用英文名：A-836339 分子式：C16H26N2O2S 分子量：310.455 密度：1.1±0.1 g/cm3 沸点：388.4±44.0 °C at 760 mmHg 熔点：N/A 闪点：188.7±28.4 °C 储存条件：2-8℃
供应商信息：
公司名：上海念兴实业有限公司 推荐
认证状态： 已认证供应商
商品数： 403768件
电话： 18916513247
地址： 2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区： 上海市普陀区
联系人： 小陈
联系人电话： 0086-021-52280163
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