Silvestrol aglycone?

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更新时间： 2026-01-21 17:05:10

CAS号：960365-65-5

常用名： Silvestrol糖苷配基

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Silvestrol aglycone, a aglycone of potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).IC50 value:Target: Apoptosis inducerin vitro: Silvestrol induced an apoptotic response, disrupted the mitochondrial trans-membrane potential and caused cytochrome c release into the cytoplasm. Immunoblot analysis indicated that, at the protein level, silvestrol produced an increase of Bcl-xl phosphorylation with a concomitant increase of bak. Furthermore, caspase-2, -9 and -10 appeared to be involved in silvestrol-mediated apoptosis. In contrast, the involvement of caspase-3 and -7 was not detected, either by immunoblot or caspase-3/-7-like activity analysis, indicating that these pathways do not play a crucial role in silvestrol-induced apoptosis [1]. The ability of silvestrol and analogues to selectively inhibit the translation of proteins with high requirement on the translation-initiation machinery (i.e., complex 5'-untranslated region UTR) relative to simple 5'UTR was determined by a cellular reporter assay. Simplified analogues of silvestrol such as compounds 74 and 76 were shown to have similar cytotoxic potency and better ADME characteristics relative to those of silvestrol [2].in vivo: 物理化学性质： CAS号：960365-65-5 常用中文名：Silvestrol糖苷配基常用英文名：Silvestrol aglycone 分子式：C27H26O8 分子量：478.49100 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

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公司名：上海念兴实业有限公司推荐

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2025-02-05 价格：￥9500.9 Silvestrol aglycone

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Silvestrol糖苷配基价格

Silvestrol aglycone?

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