托吡酯

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发布时间： 2024-07-15 12:38:02

CAS号：97240-79-4

常用名： 托吡酯

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.Target: GluR5 receptor; GABA receptorTopiramate (Topamax) is a structurally novel broad-spectrum antiepileptic drug (AED) with established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures, partial seizures with or without generalised seizures, and seizures associated with Lennox-Gastaut syndrome [1]. topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (gamma-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors [2].Topiramate (median average dosage 5.1 mg/kg/day) was also found to be useful as adjunctive therapy in the management of Lennox-Gastaut syndrome and significantly reduced the mean frequency of drop attacks by 14.8% compared with an increase of 5.1% with placebo. Further gains in seizure control were made in a nonblind extension of this trial where the mean topiramate dosage was 10 mg/kg/day. Nine of 11 patients in 1 pilot trial of children with otherwise intractable West syndrome, and 5 of 10 in another, achieved a > or =50% reduction in seizure rate with topiramate (target dosage up to 24 mg/kg/day) [3].Clinical indications: Epilepsy; Lennox Gastaut syndrome; Migraine; Seizure disorder Toxicity:abdominal pain; agitation; blurred vision; convulsions; depression; dizziness; double vision; drowsiness; impaired coordination; impaired mental activity; low blood pressure; reduced consciousness; severe diarrhea; sluggishness and speech problems. 物理化学性质： CAS号：97240-79-4 常用中文名：托吡酯常用英文名：Topiramate 分子式：C12H21NO8S 分子量：339.362 密度：1.3±0.1 g/cm3 沸点：438.7±55.0 °C at 760 mmHg 熔点：125ºC 闪点：219.1±31.5 °C 储存条件：0-10°C;避免加热

供应商信息：

公司名：上海念兴实业有限公司推荐

认证状态： 已认证供应商

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地区： 上海市普陀区

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2024-07-15 价格：需询单托吡酯

2019-03-05 价格：￥118.0 托吡酯

2022-11-29 价格：￥需询单 Topiramate

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2022-02-19 价格：￥34.9 托吡酯

2024-11-23 价格：￥3700.0 托吡酯

2018-01-28 价格：￥600.0 托吡酯

2024-04-24 价格：￥需询单托吡酯

2022-02-24 价格：￥需询单托吡酯

2018-07-31 价格：￥需询单托吡酯

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