1-(2,3-二氢-1,4-苯并二烷-5-基)哌嗪盐酸盐

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发布时间： 2024-07-15 12:38:03

CAS号：98224-03-4

常用名： 依托拉嗪

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of non-specific binding [1]. Eltoprazine evoked membrane changes that were similar to but much weaker than those induced by 5HT. Both the 5HT- and eltoprazine-evoked membrane hyperpolarizations were largely suppressed in the presence of spiperone [2].in vivo: eltoprazine is extremely effective in suppressing dyskinesia in experimental models, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa. Interestingly, eltoprazine was found to (synergistically) potentiate the antidyskinetic effect of amantadine. The current data indicated that eltoprazine is highly effective in counteracting dyskinesia in preclinical models [3]. Rats were chronically treated with mianserin (10 mg/kg i.p.) or eltoprazine (1 mg/kg i.p.) and were tested in the elevated plus-maze test for anxiety. Mianserin and eltoprazine displayed opposite effects in the elevated plus-maze: mianserin induced anxiolytic-like effects, while eltoprazine showed anxiogenic-like ones [4]. 物理化学性质： CAS号：98224-03-4 常用中文名：依托拉嗪常用英文名：Eltoprazine 分子式：C12H16N2O2 分子量：220.26800 密度：1.18g/cm3 沸点：384.3ºC at 760mmHg 熔点：N/A 闪点：186.2ºC 储存条件：-20°C，密闭，干燥

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2022-03-04 价格：￥3188.0 盐酸依托拉嗪

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1-(2,3-二氢-1,4-苯并二烷-5-基)哌嗪盐酸盐

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