rel-(R)-2-((R)-(2-乙氧基苯氧基)(苯基)甲基)吗啉甲磺酸盐

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发布时间： 2024-07-15 12:38:03

CAS号：98769-84-7

常用名： 甲磺酸瑞波西汀

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纯度： 99.0%

备货期： 10天

库存： 现货

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用途： Reboxetine Mesylate is a norepinephrine reuptake inhibitor use in the treatment of unipolar depression.Target: OthersReboxetine is a drug of the norepinephrine reuptake inhibitor class. Reboxetine dose-dependently and potently inhibits locus coeruleus neuronal firing in rats with ED50 of 191 μg/kg. Reboxetine inhibition of the locus coeruleus neurons is reversible by the α2 antagonist piperoxan (1.5 mg/kg, IV). Reboxetine dose-dependently reverses reserpine-induced blepharospasm and hypothermia in the mouse. Reboxetine is also found to antagonize clonidine-induced hypothermia dose-dependently in mice. Reboxetine reverses reserpine-induced blepharospasm and hypothermia in rats with ED50 of 10 mg/kg and 3 mg/kg (p.o.), respectively [1]. Reboxetine is associated with a markedly lower relapse rate than placebo (22% vs. 56%) and a greater cumulative probability of a maintained response during long-term treatment in patients with recurrent DSM-III-R major depression. Reboxetine effectively prevents recurrence of depressive symptoms following episode resolution [2]. Acute systemic administration of Reboxetine (0.3 mg/kg-20 mg/kg) dose-dependently increases extracellular norepinephrine in the rat frontal cortex while having no effect on extracellular serotonin. Reboxetine (20 mg/kg) also increases extracellular dopamine in the rat frontal cortex. Chronic administration of Reboxetine for 14 days results in elevated basal concentrations of extracellular norepinephrine and dopamine and a greater net increase of extracellular norepinephrine and dopamine, but not serotonin in the rat frontal cortex [3]. 物理化学性质： CAS号：98769-84-7 常用中文名：甲磺酸瑞波西汀常用英文名：Reboxetine (mesylate) 分子式：C20H27NO6S 分子量：409.496 密度：N/A 沸点：443.7ºC at 760 mmHg 熔点：170-171ºC 闪点：188.2ºC 储存条件：2-8°C

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2022-02-19 价格：￥646.9 Reboxetine mesylate

2024-05-16 价格：￥需询单甲磺酸瑞波西汀

2021-02-06 价格：￥3279.0 Reboxetine mesylate

2024-01-09 价格：$需询单 Reboxetine mesylate(98769-84-7)

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甲磺酸瑞波西汀价格

rel-(R)-2-((R)-(2-乙氧基苯氧基)(苯基)甲基)吗啉甲磺酸盐

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