HPGDSinhibitor1
产品详情：
更新时间： 2025-09-02 18:13:32
CAS号：1033836-12-2
常用名：
价格：
纯度： 98.0%
备货期： 10天
库存： 现货
其他详情（用途，包装）：
用途： HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.IC50 Value: 0.7 nM [1]Target: HPGDSHPGDS inhibitor 1 was elected for further profiling based on its enzyme and cell potency. The compound illustrated equal potency against purified HPGDS from human , rat, dog, and sheep (IC50, 0.5-2.3 nM). HPGDS inhibitor 1 was profiled in a panel of cellular assays to screen for activity against several relevant human enzyme targets. Those assay indicated that HPGDS inhibitor 1 does not inhibit human L- PGDS, m-PGDS, COX-1, COX-2 or 5 LOX (IC50 values > 10000 nM).HPGDS inhibitor 1 had a solubility of 1.5 ug/ml (3.9 uM) at pH 6.5. The compound had excellent PK characteristics when dosed in rats at 1 mpk with 76% bioavailavility. Rats dosed orally with 1 and 10 mpk HPGDS inhibitor 1 were sacrificed at various times, and plasma concentrations of HPGDS inhibitor 1 and spleen PGD2 concentrations were measured. Oral administration of HPGDS inhibitor 1 blocked PGD2 production in the rat spleen; inhibition of PGD2 was inversely correlated with the plasma concentration of HPGDS inhibitor 1 in a time and dose-dependent manner. Spleen PGD2 levels fall as HPGDS inhibitor 1 plasma levels increase over time; PGD2 levels return to baseline levels as HPGDS inhibitor 1 plasma levels decline. 物理化学性质： CAS号：1033836-12-2 常用中文名：HPGDS抑制剂1 常用英文名：HPGDS inhibitor 1 分子式：C19H19F4N3O 分子量：381.367 密度：1.3±0.1 g/cm3 沸点：487.2±45.0 °C at 760 mmHg 熔点：N/A 闪点：248.5±28.7 °C 储存条件：-20℃
供应商信息：
公司名：上海化源世纪贸易有限公司 推荐
认证状态： 已认证供应商
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化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
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其他供应商价格：
2021-02-06 价格：￥10033.0
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HPGDSinhibitor1价格为, 由HPGDSinhibitor1生产厂家上海化源世纪贸易有限公司提供，供应信息包括纯度，备货期/库存，供货能力等。>>电脑版：HPGDSinhibitor1_价格_生产厂家【上海化源世纪贸易有限公司】
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