拉扎贝胺

产品详情：

更新时间： 2025-08-31 21:37:32

CAS号：103878-84-8

常用名： 拉扎贝胺

价格：

纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Lazabemide(Ro 19-6327/000) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).IC50 value: 30 nM [1]Target: MAO-B inhibitorin vitro: The in vitro binding characteristics of both radiolabeled inhibitors revealed them to be selective, high-affinity ligands for the respective enzymes. KD and Bmax values for 3H-Ro 41-1049 in rat cerebral cortex were 10.7 nM and 7.38 pmol/mg protein, respectively, and for 3H-Ro 19-6327 were 18.4 nM and 3.45 pmol/mg protein, respectively [1]. The IC50 values for lazabemide and Ro 16-6491, respectively, were: 86 microM and 90 microM for NA uptake; 123 microM and 90 microM for 5HT uptake; > 500 microM and > 1000 microM for DA uptake. Lazabemide and Ro 16-6491 also differed from L-deprenyl in their ability to induce release of endogenous monoamines from synaptosomes. Thus, Ro 16-6491 (500 microM) induced a greater 5 HT release than did L-deprenyl, but was less effective than L-deprenyl in releasing DA. On the contrary, lazabemide was almost completely inactive on either 5 HT and DA release [2]. a clear inhibition of DOPAC formation was observed with Ro 41-1049 (250 nM), while 250 nM lazabemide was found not to increase the accumulation of newly-formed DA in those tubular epithelial cells loaded with 50 microM L-DOPA [3].in vivo: The ischemia reperfusion-induced hydroxyl radical generation was attenuated by 3 mg/kg of clorgyline and lazabemide. Furthermore, mice pretreated with these MAO inhibitors showed decreased DOPAC levels in comparison with those of their respective vehicle-treated control groups; recovery of the reduced DOPAC level was also delayed [4]. 物理化学性质： CAS号：103878-84-8 常用中文名：拉扎贝胺常用英文名：Lazabemide 分子式：C8H10ClN3O 分子量：199.637 密度：1.3±0.1 g/cm3 沸点：397.4±37.0 °C at 760 mmHg 熔点：N/A 闪点：194.2±26.5 °C 储存条件：2-8℃

供应商信息：

公司名：上海化源生化科技有限公司推荐

认证状态： 已认证供应商

商品数： 396718件

电话： 53555033

地址： 上海市普陀区金沙江路1759号圣诺亚大厦B座508室

地区： 上海市普陀区

联系人： 徐经理

联系人电话： 133 1186 9306

邮件：xuqm@chemsrc.com

网址：http://www.chemsrc.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：
【化源网 · 专业化学品一站式商城】
700万SKU，产品全，价格优，智能高效。

★同时支持商城系统搭建：
ERP &小程序 & 产品国内/海外推广（广告）

详情咨询: 133 1186 9306（微信同号）

其他供应商价格：

2022-11-29 价格：￥需询单 Lazabemide

2021-04-03 价格：￥2180.0 Lazabemide

2024-03-12 价格：￥399.9 拉扎贝胺

查看所有价格请点击：

拉扎贝胺价格

拉扎贝胺

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：