GSK256066(2,2,2-trifluoroaceticacid)

产品详情：

更新时间： 2025-09-06 14:22:50

CAS号：1415560-64-3

常用名： GSK 256066三氟乙酸盐

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.IC50 value: 3.2 pM [1]Target: PDE4Bin vitro: GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. GSK256066 is an extremely potent inhibitor of LPS-stimulated TNFα production in PBMCs with pIC50 of 11.0 and IC50 of 10 pM and human whole-blood cultures with pIC50 of 9.90 and IC50 of 126 pM. GSK256066 is highly selective for PDE4 (>3.8 × 105-fold versus PDE1, PDE2, PDE3, PDE5, and PDE6 and >2.5 × 103-fold against PDE7). GSK256066 inhibits PDE4 isoforms A-D with equal affinity [1].in vivo: GSK256066 inhibits the LPS-induced pulmonary neutrophilia with an ED50 of 1.1 μg/kg, achieving maximal inhibition of 72% at 30 μg/kg when given in the aqueous suspension. GSK256066 inhibits the LPS-induced pulmonary neutrophilia with ED50 of 2.9 μg/kg, achieving maximal inhibition of 62% when given in the dry powder formulation. GSK256066 shows a moderate plasma clearance of 39 ml/min/kg, a moderate volume of distribution of 0.8 L/kg, and a relatively short half-life of 1.1 hour in the male CD rat [1]. GSK256066 sustains at a high lung concentration of 2.6 μg/g after intra-tracheal administration as an aqueous suspension at a dose of 30 μg/kg in rats [2]. GSK256066 (10 μg/kg) is administered intratracheally at different times (2, 6, 12, 18, 24, and 36 hours) before LPS administration, inhibiting LPS-Induced Pulmonary Neutrophilia in rat lipopolysaccharide (LPS)-induced models of acute pulmonary inflammation. GSK256066 (0.3–100 μg/kg) inhibits LPS-induced increases in exhaled nitric oxide with ED50 of 35 μg/kg in rat. GSK256066 (10 μg/kg) is administered half a hour before OVA administration in rat, inhibiting OVA-induced pulmonary eosinophilia with ED50 of 0.4 μg/kg. GSK256066 administered intratracheally as a dry powder blended in respiratory-grade lactose at doses of 3 to 100 μg/kg 2 hours before inhaled LPS challenge in ferrets, inhibiting LPS-induced pulmonary neutrophilia with ED50 of 18 μg/kg without inducing emetic episodes [3]. 物理化学性质： CAS号：1415560-64-3 常用中文名：GSK 256066三氟乙酸盐常用英文名：GSK256066 (2,2,2-trifluoroacetic acid) 分子式：C29H27F3N4O7S 分子量：632.60700 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

供应商信息：

公司名：上海化源生化科技有限公司推荐

认证状态： 已认证供应商

商品数： 396718件

电话： 53555033

地址： 上海市普陀区金沙江路1759号圣诺亚大厦B座508室

地区： 上海市普陀区

联系人： 化源

联系人电话： 13311869306

邮件：xuqm@chemsrc.com

网址：http://www.chemsrc.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：
【化源网 · 专业化学品一站式商城】--www.echemsrc.com
700万SKU，一站式采购；

同时支持系统搭建业务：
ERP 管理系统
DMS 分销系统（可 1:1 复刻化源前端+后台）
小程序 / APP / 独立站定制
从商品库、订单流、仓储、财务到客户管理，全链路打通。

产品咨询：177 1745 3229 ；商城/ERP搭建: 133 1186 9306

其他供应商价格：

2025-02-05 价格：￥6696.9 GSK256066 Trifluoroacetate

查看所有价格请点击：

GSK 256066三氟乙酸盐价格

GSK256066(2,2,2-trifluoroaceticacid)

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：