角鲨胺

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更新时间： 2025-09-03 18:42:36

CAS号：148717-90-2

常用名： 角鲨胺

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity.IC50 value: Target: in vitro: squalamine can strongly displace membrane-bound cationic proteins such as Rac1, a ρ-GTPase recruited to the inner leaflet of the eukaryotic cytoplasmic membrane for the actin remodeling necessary for endocytosis. At concentrations between 20 and 60 μg/mL, squalamine has been shown to inhibit a broad array of growth factor-induced, actin-dependent responses in endothelial cells, including cell migration, cell division, and vascular tube formation in a 3D matrix [1]. Squalamine effectively inhibited HBV replication in human primary hepatocytes when added either during the initial exposure of virus to the cells or at 24 h after infection. A similar study was performed to evaluate the effect of squalamine on the replication of HDV. Squalamine was introduced at 20 μg/mL during HDV exposure, and the effects were measured at day 7 when total RNA was extracted and assayed for HDV RNA sequences [1]. in vivo: one time daily treatment with squalamine (15 or 30 mg/kg per d s.c.) was started beginning on day 1 or 2 after viral administration and continuing until day 8 or 9, respectively. Survival was monitored, and animals that remained alive by day 21 were considered cured [1]. 物理化学性质： CAS号：148717-90-2 常用中文名：角鲨胺常用英文名：Squalamine 分子式：C34H65N3O5S 分子量：627.96200 密度：1.13g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20°C

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2022-09-23 价格：￥10556.0 角鲨胺

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角鲨胺

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