RJR-2403

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发布时间： 2024-07-15 12:32:30

CAS号：15585-43-0

常用名： Rivanicline

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Rivanicline (RJR-2403) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).IC50 value: 26 nM [1]Target: α4β2 nAChRin vitro: At concentrations up to 1 mM, Rivanicline does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves for agonist-induced ileum contraction indicate that Rivanicline is less than one-tenth as potent as nicotine with greatly reduced efficacy. Rivanicline does not antagonize nicotine-stimulated muscle or ganglionic nAChR function (IC50 > 1 mM). Chronic exposure of M10 cells to Rivanicline (10 microM) results in an up-regulation of high-affinity nAChRs phenomenologically similar to that seen with nicotine [1].in vivo: Rivanicline significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. By comparison, Rivanicline was 15 to 30-fold less potent than nicotine in decreasing body temperature, respiration, Y-maze rears and crosses and acoustic startle response [2]. Metanicotine was about 5-fold less potent than nicotine in the tail-flick test after s.c administration, but slightly more potent after central administration [3]. 物理化学性质： CAS号：15585-43-0 常用中文名：Rivanicline 常用英文名：RJR-2403 分子式：C10H14N2 分子量：162.23200 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

认证状态： 已认证供应商

商品数： 396743件

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联系人： 徐乾明

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邮件：xuqm@chemsrc.com

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2022-11-29 价格：￥需询单 RJR-2403

2022-03-04 价格：￥2302.0 RJR-2403

2021-12-23 价格：￥1657.0 [Perfemiker]Rivanicline,98%

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RJR-2403

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