5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚嗪并[2,3-B]喹喔啉

产品详情：

发布时间： 2024-07-15 12:32:42

CAS号：163769-88-8

常用名： YM-90709

价格：

纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： YM-90709 is a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor.Target: IL-5in vitro: YM-90709 potently inhibits the binding of 100 pM [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0±0.40 and 0.57±0.21 μM, respectively. YM-90709 inhibits the 4 pM IL-5-induced effect in a concentration-dependent manner with an IC50 value of 0.45±0.024 μM. YM-90709 also inhibits the higher concentrations (12 and 40 pM) of IL-5-induced effects with IC50 values of 0.89±029 and 1.0±0.22 μM, respectively. [1] YM-90709 is a novel interleukin-5 receptor antagonist, YM-90709 inhibits antigen-induced eosinophil recruitment into the airway, the same as anti-IL-5 mAb does. YM-90709 inhibits the binding of IL-5 to IL-5R on human eosinophils, but did not inhibit the binding of GM-CSF to GM-CSFR. In addition, YM-90709 inhibits IL-5-induced, but not GM-CSF-induced, eosinophil survival as well as the tyrosine phosphorylation of Janus kinase 2. [2]in vivo: YM-90709 suppresses antigen-induced airway inflammation in Brown Norway rats . YM-90709 is a novel IL-5R antagonist with those of anit-IL-5 mAb on the antigen-induced infiltration of eosinophils into the airways of BDF1 mice, a strain that is commonly used in the antibody estimation. [2] This is the first report on the examination of the effects of YM-90709 in vivo, as a novel IL-5R antagonist on the antigen-induced infiltration of eosinophils and other leukocytes into the BALF of Brown-Norway (BN) rats. [3] 物理化学性质： CAS号：163769-88-8 常用中文名：YM-90709 常用英文名：YM-90709 分子式：C22H21N3O2 分子量：359.421 密度：1.3±0.1 g/cm3 沸点：579.6±50.0 °C at 760 mmHg 熔点：N/A 闪点：304.3±30.1 °C 储存条件：-20℃

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

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其他供应商价格：

2022-11-29 价格：￥需询单 YM 90709

2021-02-06 价格：￥5389.0 YM 90709

2022-02-19 价格：￥834.9 YM 90709

2021-12-23 价格：￥471.0 [Perfemiker]5，6-二氢-2，3-二甲氧基-6，6-二甲基苯并[7，8]吲哚嗪并[2，3-B]喹喔啉,99%

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5,6-二氢-2,3-二甲氧基-6,6-二甲基苯并[7,8]吲哚嗪并[2,3-B]喹喔啉

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