度他雄胺

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更新时间： 2025-08-21 17:28:45

CAS号：164656-23-9

常用名： 度他雄胺

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纯度： 99.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Dutasteride (GG745) is a potent inhibitor of both 5 alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.IC50 Value:Target: 5 alpha-reductasein vitro: Dutasteride inhibited (3)H-T conversion to (3)H-DHT and, as anticipated, inhibited T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC(50) approximately 1 microM). Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 microM. High concentrations of dutasteride (10-50 microM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis [1]. Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].in vivo: GG745 has a terminal half-life of approximately 240 hr, and single doses of >10 mg decreased DHT levels significantly more than did single 5-mg doses of finasteride [3]. In placebo treated men without prostate cancer there was an 8.3% median increase in PSA at month 24 compared with -59.5% in those who received dutasteride, using doubled values to correct for dutasteride treatment [4].Toxicity: Dutasteride may affect male fertility and steroid hormone dynamics. Therefore, a 21-day reproduction study was conducted to determine the effects of dutasteride (10, 32 and 100 μg/L) on fish reproduction. Exposure to dutasteride significantly reduced fecundity of fish and affected several aspects of reproductive endocrine functions in both males and females [5].Clinical trial: Bioequivalence Study Of Dutasteride Five 0.1 mg And One 0.5 mg Soft Gelatin Capsules In Healthy Male Volunteers. Phase 1 物理化学性质： CAS号：164656-23-9 常用中文名：度他雄胺常用英文名：Dutasteride 分子式：C27H30F6N2O2 分子量：528.530 密度：1.3±0.1 g/cm3 沸点：620.3±55.0 °C at 760 mmHg 熔点：242-250ºC 闪点：329.0±31.5 °C 储存条件：-20°C Freezer

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公司名：上海化源世纪贸易有限公司推荐

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化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-02-19 价格：￥247.9 Dutasteride

2025-09-17 价格：￥需询单度他雄胺

2023-11-18 价格：￥需询单 Dutasteride

2018-03-01 价格：￥100.0 度他雄胺

2018-05-08 价格：￥需询单度他雄胺

2023-06-21 价格：￥需询单度他雄胺

2017-06-27 价格：￥需询单度他雄胺

2018-03-23 价格：￥需询单度他雄胺

2023-07-25 价格：￥14.0 度他雄胺

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度他雄胺价格

度他雄胺

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