泽泻醇B

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发布时间： 2024-07-15 12:33:09

CAS号：18649-93-9

常用名： 泽泻醇B

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions.IC50 Value:Target:In vitro: The in vitro cultured human renal tubular epithelial HK-2 cells were intervened with 5 ng/mL transforming growth factor-beta (TGF-beta), 0.1 micromol C3a, and 0.1 micromol C3a + 10 micromol alisol B, respectively. Exogenous C3a could induce renal tubular EMT. Alisol B was capable of suppressing C3a induced EMT [1]. Alisol-B strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that alisol-B acts on osteoclast precursors to inhibit RANKL/RANK signaling. Among the RANK signaling pathways, alisol-B inhibited the phosphorylation of JNK, which are upregulated in response to RANKL in bone marrow macrophages, alisol-B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. In addition, alisol-B suppressed the pit-forming activity and disrupted the actin ring formation of mature osteoclasts [2]. Alisol B induced calcium mobilization from internal stores, leading to autophagy through the activation of the CaMKK-AMPK-mammalian target of rapamycin pathway. Moreover, the disruption of calcium homeostasis induces endoplasmic reticulum stress and unfolded protein responses in alisol B-treated cells, leading to apoptotic cell death. Finally, by computational virtual docking analysis and biochemical assays, it was showed that the molecular target of alisol B is the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase [3].In vivo: 物理化学性质： CAS号：18649-93-9 常用中文名：泽泻醇B 常用英文名：Alisol B 分子式：C30H48O4 分子量：472.70 密度：1.1±0.1 g/cm3 沸点：567.1±50.0 °C at 760 mmHg 熔点：N/A 闪点：181.2±23.6 °C 储存条件：-20℃

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

认证状态： 已认证供应商

商品数： 396724件

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其他供应商价格：

2024-09-29 价格：￥需询单泽泻醇B

2019-03-05 价格：￥2828.0 泽泻醇B

2021-12-23 价格：￥2291.0 [Perfemiker]泽泻醇B,95%

2024-03-12 价格：￥1259.9 泽泻醇B

2024-02-29 价格：￥30000.0 泽泻醇B

2016-10-29 价格：￥2880.0 泽泻醇 B

2017-07-04 价格：￥需询单泽泻醇B

2023-12-13 价格：￥300.0 泽泻醇B

2017-10-02 价格：￥需询单泽泻醇B

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