盐酸胺碘酮

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更新时间： 2025-08-29 13:23:24

CAS号：19774-82-4

常用名： 盐酸胺碘酮

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM. IC50 Value: 1.5 uM ( inhibit TBARS, LOOH and FPL formation)[1]in vitro: It was found that 10 uM amiodarone induces accumulation of ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae cells. At the same time, in yeast cells with inactivated MDR genes, accumulation of ethidium bromide was 6-fold higher even without amiodarone. Addition of non-lethal concentrations of amiodarone to MDR-deficient cells caused an increase of intracellular ethidium bromide to the level, which was even lower than the level in amiodarone-treated wild-type cells [2]. Cells treated with amiodarone were seen to have detached from the dish, with cell rounding, cytoplasmic blebbing and irregularity in shape. An increase in the sub-G1 phase fraction, from 15.43 to 21.34% and 79.83% and a reduction in the G1 phase fraction, from 48.83 to 41.63% and 11.52%, were observed in cells treated with amiodarone at concentrations of 0.1 and 1 mM, respectively [3].in vivo: Chronic treatment with oral amiodarone for 4 weeks reduced i.p. when myocytes were dialyzed with patch-pipettes containing either 10 mM Na+ or 80 mM Na+. In myocytes from untreated rabbits, acute exposure to amiodarone in vitro reduced i.p. when patch pipettes contained 10 mM Na+ but had no effect on i.p. at 80 mM Na+. Amiodarone had no effect on the voltage dependence of the pump or the affinity of the pump for extracellular K+ either after chronic treatment or during acute exposure [4].Clinical trial: Continuous Versus Episodic Amiodarone Treatment for the Prevention of Permanent Atrial Fibrillation . Phase not specified 物理化学性质： CAS号：19774-82-4 常用中文名：盐酸胺碘酮常用英文名：Amiodarone HCl 分子式：C25H30ClI2NO3 分子量：681.773 密度：1.58 g/cm3 沸点：635.1ºC at 760 mmHg 熔点：154-158°C 闪点：337.9ºC 储存条件：2-8°C

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公司名：上海化源世纪贸易有限公司推荐

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公司介绍：
化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-02-19 价格：￥124.9 胺碘酮盐酸盐

2019-03-05 价格：￥788.0 胺碘酮盐酸盐

2022-09-16 价格：￥需询单盐酸胺碘酮

2024-09-13 价格：￥需询单盐酸胺碘酮

2017-06-18 价格：￥需询单盐酸胺碘酮

2021-03-26 价格：￥需询单盐酸胺碘酮

2018-10-24 价格：￥需询单盐酸胺碘酮 19774-82-4

2022-10-20 价格：￥需询单 Amiodarone Hcl

2020-12-08 价格：￥570.0 盐酸胺碘酮

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