牛蒡子苷

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发布时间： 2024-07-15 12:33:27

CAS号：20362-31-6

常用名： 牛蒡子苷

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. IC50 Value:Target: Othersin vitro: Treatment of PC-3 cells with arctiin decreased the cell number in a concentration- and time-dependent manner in serum-containing condition. Arctiin preferentially induced cell detachment, but did not have anti-proliferation or cytotoxic effects in PC-3 cells. The arctiin-induced effect was inhibited by cycloheximide, indicating that protein synthesis was required [1]. Although arctiin, the active component of AL that has been described in the literature, was not able to reduce degranulation in RBL-2H3 cells, a single high-performance liquid chromatography (HPLC) fraction from the AL extract inhibited beta-hexosaminidase release (IC(50) = 22.2 microg/ml) [2]. The growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Furthermore, thearctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. Depletion of the cyclin D1 protein using small interfering RNA-rendered human breast cancer MCF-7 cells insensitive to the growth inhibitory effects of arctiin, implicates cyclin D1 as an important target of arctiin [6]. in vivo: Histopathological evaluation of prostate revealed that all the rats in any group developed adenocarcinoma in dorsolateral lobe of prostate, except two rats in 0.1% arctiin treated and one rat in 0.002% arctiin treated groups without prostate adenocarcinoma development [3]. After oral administration of arctiin (30, 60, 120 mg/kgd) for three weeks, the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) and 24-h urine protein content markedly decreased, while endogenous creatinine clearance rate (ECcr) significantly increased [4]. STZ-induced diabetic rats were treated witharctiin at the dosage of 60 or 40 mg/kg/day via intraperitoneal injection for 8 weeks. Blood glucose and 24-h urinary albumin content were measured, and kidney histopathological changes were monitored [5]. 物理化学性质： CAS号：20362-31-6 常用中文名：牛蒡子苷常用英文名：Arctiin 分子式：C27H34O11 分子量：534.552 密度：1.4±0.1 g/cm3 沸点：756.4±60.0 °C at 760 mmHg 熔点：109 °C 闪点：250.1±26.4 °C 储存条件：?20°C

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

认证状态： 已认证供应商

商品数： 396724件

电话： 13311869306

地址： 上海市普陀区金沙江路1759号圣诺亚大厦A座1116室

地区： 上海市普陀区

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联系人电话： 13311869306

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其他供应商价格：

2024-09-29 价格：￥需询单牛蒡子苷

2019-03-05 价格：￥118.0 牛蒡子苷/牛蒡苷

2022-11-29 价格：￥需询单 Arctiin(NSC 315527)

2021-02-06 价格：￥569.0 Arctiin

2021-12-23 价格：￥168.0 [Perfemiker]牛蒡子苷,分析对照品

2022-02-19 价格：￥247.9 牛蒡子苷

2024-09-13 价格：￥需询单牛蒡苷，牛蒡子苷

2018-03-25 价格：￥需询单牛蒡子苷

2016-04-30 价格：￥120.0 牛蒡子苷

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牛蒡子苷

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