2-甲基-6-(苯基炔基)吡啶盐酸盐

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更新时间： 2025-09-15 11:57:15

CAS号：219911-35-0

常用名： MPEP盐酸盐

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纯度： 98.0%

备货期： 10天

库存： 现货

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用途： MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.IC50 Value: 36 nMTarget: mGluRin vitro: MPEP has no appreciable agonist or antagonist activity at the closely related recombinant human mGlu1b receptor expressed in CHO-K1 cells or a purinoreceptor endogenously expressed in L(tk-) cells up to concentrations of 100 μM. Furthermore, MPEP shows no appreciable agonist or antagonist activity in cAMP accumulation or [35S]-GTPγS binding assays at the recombinant human group II and III metabotropic receptors (human mGlu2, -3, -4a, -6, -7b, -8a) as well as the human NMDA (NMDAR1A/2A, -1A/2B), rat AMPA (GluR3) and human kainate (GluR6) receptor subtypes. In slices of rat neonatal hippocampus, striatum, and cortex but not cerebellum, MPEP inhibits DHPG-stimulated PI hydrolysis with IC50 of 8.0 nM, 20.5 nM, and 17.9 nM, respectively. MPEP positively modulates the hmGluR4 in a recombinant expression system, and the effect of MPEP is fully dependent on the activation of the orthosteric agonist L-AP4.in vivo: MPEP (1-30 mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice. MPEP (1-20 mg/kg) shortens the immobility time in a tail suspension test in mice, but it is inactive in the behavioural despair test in rats. MPEP has no effect on locomotor activity or motor coordination. MPEP significantly reduces fmr1 but not wild-type center square entries and duration. In open field tests, MPEP reduces fmr1tm1Cgr center field behavior to one indistinguishable from wild-type. MPEP produces a significant reduction of total locomotor activity in three of four groups tested, at both 10 mg/kg and 30 mg/kg. 物理化学性质： CAS号：219911-35-0 常用中文名：MPEP盐酸盐常用英文名：MPEP (Hydrochloride) 分子式：C14H12ClN 分子量：229.705 密度：1.1g/cm3 沸点：336.3ºC at 760mmHg 熔点：N/A 闪点：144.8ºC 储存条件：-20℃

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其他供应商价格：

2022-03-04 价格：￥196.9 MPEP 盐酸盐

2025-09-17 价格：￥需询单 2-甲基-6-(苯基炔基)吡啶盐酸盐

2021-02-06 价格：￥2369.0 MPEP Hydrochloride

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MPEP盐酸盐价格

2-甲基-6-(苯基炔基)吡啶盐酸盐

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