N-甲基-N-(4-甲基-5-氨磺酰基噻唑-2-基)-2-(4-(吡啶-2-基)苯基)乙酰胺

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更新时间： 2025-09-09 18:52:33

CAS号：348086-71-5

常用名： 普瑞利韦

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.IC50 Value: 20 nM (HSV-1) [1]Target: HSVin vitro: BAY 57-1293 is nearly two orders of magnitude more potent than acyclovirin vitro and the superiority was even more prominent when the viral load was increased (BAY 57-1293 IC50 = 12 nM, 20 nM and 50 nM; acyclovir IC50 = 1uM, 3M and 10 50 uM at a multiplicity of infection (m.o.i.) of 0.0025, 0.02 and 0.2, respectively). A minor increase in IC50 values at higher viral loads was observed for all thiazolyl compounds listed in Table 1. BAY 57-1293 was also active against porcine (IC50 = 5 uM) and bovine (IC50 = 0.12 uM) herpes strains [1].in vivo: Delayed treatment with BAY 57-1293 (20 mg/kg 2× daily per os, treatment day 4-14) abrogates progression of disease symptoms (mean of 10 animals per group) of HSV-2 infected guinea pigs within 1 d of treatment and healing is observed subsequently, whereas a 7.5 fold higher dose of valacyclovir (150 mg/kg 2× daily) shows marginal therapeutic efficacy compared with placebo [1]. The compound given orally, or intraperitoneally once per day at a dose of 15 mg/kg for 4 successive days was equally effective or superior to a much higher dose of famciclovir (1mg/ml, i.e. approximately 140-200mg/kg/day) given in the drinking water for 7 consecutive days, which, in our hands, is the most effective method for administering famciclovir to mice [2].Toxicity: Exploratory toxicology and safety pharmacology studies did not reveal any safety relevant findings at 30, 100 and 300 mg/kg BAY 57-1293 (once daily per os) in a 4-week chronic toxicity study in dogs. However, administration of the same dose to rats for 4 weeks resulted in a dose-dependent transitional hyperplasia of the urinary bladder epithelium [1]. 物理化学性质： CAS号：348086-71-5 常用中文名：普瑞利韦常用英文名：BAY 57-1293 分子式：C18H18N4O3S2 分子量：402.491 密度：1.4±0.1 g/cm3 沸点：639.4±65.0 °C at 760 mmHg 熔点：N/A 闪点：340.5±34.3 °C 储存条件：2-8℃，干燥

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公司名：上海化源世纪贸易有限公司推荐

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化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-03-04 价格：￥205.9 BAY 57-1293

2023-03-21 价格：￥需询单 BAY-57-1293;Pritelivir

2021-05-10 价格：￥需询单 BAY-57-1293

2017-08-06 价格：￥需询单 BAY57-1293

2018-02-27 价格：￥需询单 BAY57-1293

2023-09-13 价格：￥需询单 BAY57-1293

2021-02-06 价格：￥5219.0 BAY 57-1293

2022-05-12 价格：$需询单 Pritelivir

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普瑞利韦价格

N-甲基-N-(4-甲基-5-氨磺酰基噻唑-2-基)-2-(4-(吡啶-2-基)苯基)乙酰胺

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