苦参碱
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发布时间: 2024-07-15 12:35:34
CAS号:519-02-8
常用名:
价格:
纯度: 98.0%
备货期: 10天
库存: 现货
其他详情(用途,包装):
用途: Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.IC50 Value: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1]Target: u-receptor/kappa opioid in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhibition (IC50) was found to be 540 μg/ml. This anti-tumor function was achieved through modulation of the NF-κB, XIAP, CIAP, and p-ERK proteins expression in cell line MNK45. Matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose- and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC) [2].in vivo: Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction [3]. high dose of matrine significantly reduced the mortality rate of mice with LPS administration. Treatment with matrine improved LPS-induced lung histopathologic changes, alleviated pulmonary edema and lung vascular leak, inhibited MPO and MDA activity,and reduced the production of inflammatory mediators including TNF-α, IL-6 and HMGB1 [4].Toxicity: N/AClinical trial: N/A 作用: 0.3%~1%苦参碱溶液对乙型链球菌、痢疾杆菌、变形杆菌、大肠杆菌、金黄色葡葡球菌、绿脓杆菌均有较强的抑制作用,7.5%~10%的氧化苦参碱对痢疾、大肠杆菌、金黄色葡葡球菌、乙型链球菌也有抑制作用。另有报道苦参总碱对结核杆菌、霍乱弧菌、麻风杆菌、皮肤致病性真菌及钩端螺旋体等病原体也都有一定抑制杀灭作用。另外,山豆根水煎剂中含有抗Cox B5病毒的活性物质。具有一定的抗病毒作用。 苦参碱物理化学性质密度:1.16g/cm 3 沸点:396.7°C at 760 mmHg 闪点:172.7°C 蒸汽压:1.67E-06mmHg at 25°C 物理化学性质: CAS号:519-02-8 常用中文名:苦参碱 常用英文名:Matrine 分子式:C15H24N2O 分子量:248.364 密度:1.2±0.1 g/cm3 沸点:396.7±31.0 °C at 760 mmHg 熔点:77°C 闪点:172.7±17.2 °C 储存条件:库房低温,通风,干燥
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公司名:上海化源世纪贸易有限公司 推荐
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苦参碱价格为, 由苦参碱生产厂家上海化源世纪贸易有限公司提供,供应信息包括纯度,备货期/库存,供货能力等。>>电脑版:苦参碱_价格_生产厂家【上海化源世纪贸易有限公司】
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