乙胺嘧啶

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更新时间： 2025-08-20 18:06:59

CAS号：58-14-0

常用名： 乙胺嘧啶

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纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).IC50 Value: 15.4 nM (Plasmodium falciparum) [1]Target: DHFR; antifolatein vitro: Three susceptibility levels (susceptible, intermediate, and resistant) were observed in the response of culture-adapted clones and strains to pyrimethamine (50% inhibitory concentration [IC50]) 2,000 nM) and cycloguanil (IC50 500 nM). Based on these susceptibility levels, 73 and 68 of 96 fresh clinical isolates were susceptible to pyrimethamine (mean IC50 15.4 nM) and cycloguanil (mean IC50 11.1 nM), respectively [1]. We tested pyrimethamine(previously reported to suppress SOD1 expression), several compounds currently in trials in human and murine ALS, and a set of 1040 FDA-approved compounds. In a PC12 cell-based assay, no compounds reduced SOD1 promoter activity without concomitant cytotoxicity. Additionally,pyrimethamine failed to repress levels of SOD1 protein in HeLa cells or homogenates of liver, spinal cord and brain of wild-type mice [3].in vivo: (131)I-Pyrimethamine (specific activity: 7.08 MBq/ mol) was injected intravenously into the tail vein of the control and infected rats. Static whole body images of the rats were acquired under the gamma camera at 5 min, 45 min, 2 h, 6 h, and 24 h following the intravenous administration of the radioactivity (3.7 MBq/rat) [2]. The 10-day treatment with 10mg/kg/day of fluconazole combined with 40/1mg/kg/day sulfadiazine and pyrimethamine resulted in 93% survival of CF1 mice acutely infected with the highly virulent T. gondii RH strain, versus 36% of mice treated with just sulfadiazine and pyrimethamine [4].Toxicity: Sulfadoxine/pyrimethamine is well tolerated as treatment and when used as intermittent preventive treatment in pregnant African women. Sulfadoxine/pyrimethamine is no longer used as prophylaxis because it may cause toxic epidermal necrolysis and Stevens Johnson syndrome [5]. 物理化学性质： CAS号：58-14-0 常用中文名：乙胺嘧啶常用英文名：pyrimethamine 分子式：C12H13ClN4 分子量：248.711 密度：1.4±0.1 g/cm3 沸点：368.4±52.0 °C at 760 mmHg 熔点：233-234°C 闪点：176.6±30.7 °C 储存条件：0-6°C

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

认证状态： 已认证供应商

商品数： 396716件

电话： 53555033

地址： 上海市普陀区金沙江路1759号圣诺亚大厦B座

地区： 上海市普陀区

联系人： 徐经理

联系人电话： 13311869306

邮件：xuqm@chemsrc.com

网址：http://www.chemsrc.com

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公司介绍：
化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-02-19 价格：￥102.9 乙胺嘧啶

2019-03-05 价格：￥668.0 乙胺嘧啶

2018-01-31 价格：￥需询单乙胺嘧啶

2021-02-06 价格：￥619.0 Pyrimethamine

2017-10-18 价格：￥需询单乙胺嘧啶

2018-06-07 价格：￥需询单乙胺嘧啶

2024-01-09 价格：$需询单 Pyrimethamine API

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