R1530

产品详情：

更新时间： 2025-08-29 19:14:42

CAS号：882531-87-5

常用名： 5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities. IC50 Value: Target: VEGFR; PDGFRR1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.in vitro: In the presence of R1530, polyploid cancer cells underwent apoptosis or became senescent which translated into potent in vitro and in vivo efficacy. Normal proliferating cells were resistant to R1530-induced polyploidy thus supporting the rationale for cancer therapy by induced polyploidy. Mitotic checkpoint kinase BubR1 was found downregulated during R1530-induced exit from mitosis, a likely consequence of PLK4 inhibition [1]. R1530 strongly inhibited human tumor cell proliferation. Growth factor-driven proliferation of endothelial and fibroblast cells was also inhibited [2].in vivo: Significant tumor growth inhibition was demonstrated in a lung cancer xenograft model with a range of once daily, weekly and twice-weekly doses of R1530 (3.125-50 mg/kg qd, 100 mg/kg qw, 100 mg/kg biw). Daily doses were most effective in the lung cancer model and also had significant growth inhibitory effects in models of colorectal, prostate, and breast tumors. Tumor regression occurred in all models treated with the maximum tolerated daily dose (50 mg/kg). The doses of 25 and 50 mg/kg qd resulted in biologically significant increased survival in all tested models. After oral administration in nude mice, R1530 showed good tissue penetration. Exposure was dose dependent up to 100 mg/kg with oral administration [2].Toxicity: N/AClinical trial: A Multiple Ascending Dose Study of R-1530 in Patients With Advanced Solid Tumors. Phase 1 物理化学性质： CAS号：882531-87-5 常用中文名：5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓常用英文名：R1530 分子式：C18H14ClFN4O 分子量：356.781 密度：1.5±0.1 g/cm3 沸点：496.4±55.0 °C at 760 mmHg 熔点：N/A 闪点：254.0±31.5 °C 储存条件：2-8℃

供应商信息：

公司名：上海化源世纪贸易有限公司推荐

认证状态： 已认证供应商

商品数： 396716件

电话： 53555033

地址： 上海市普陀区金沙江路1759号圣诺亚大厦B座

地区： 上海市普陀区

联系人： 徐经理

联系人电话： 13311869306

邮件：xuqm@chemsrc.com

网址：http://www.chemsrc.com

主要市场：

年贸易额：

外贸占销售比例：

主要合作伙伴：

公司介绍：
化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-03-04 价格：￥645.9 R1530

2020-12-08 价格：￥1149.0 5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓

2023-09-20 价格：￥需询单 R1530

2019-01-03 价格：￥需询单 R-1530

查看所有价格请点击：

5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓价格

R1530

产品详情：

供应商信息：

推荐生产厂家/供应商：

其他供应商价格：

相关产品价格：