硝酸舍他康唑

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更新时间： 2025-08-29 11:37:58

CAS号：99592-39-9

常用名： 硝酸舍他康唑

价格：

纯度： 98.0%

备货期： 10天

库存： 现货

其他详情（用途，包装）：
用途： Sertaconazole nitrate is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.Target: AntifungalSertaconazole nitrate reduces the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation in a dose-dependent fashion. Sertaconazole nitrate is found to inhibit the proliferation of stimulated human lymphocytes with IC50 of 4 μg/mL [1]. Sertaconazole nitrate inhibits ergosterol synthesis by blockade of the P450-dependent enzyme pathway that catalyzes the methylation of lanosterol to ergosterol, thus inhibits fungal cell growth. Sertaconazole nitrate binds directly to nonsterol lipids in the membrane, which interferes with the regulation of the permeability of fungal cell membranes, thus induces fungal cell death [2].The mean ear weight of Tetradecanoyl phorbol acetate (TPA)-challenged murine treated with sertaconazole nitrate (1%) is 7.23 mg compared with 14.7 mg for controls, indicating a statistically significant reduction in irritant dermatitis. Sertaconazole nitrate 1% elicits a significant reduction in Resiniferatoxin-induced ear edema when compared with controls in CD-1 mice. Topical treatment with sertaconazole nitrate 1% significantly inhibits contact hypersensitivity and decreases the content of the pro-inflammatory cytokines TNFα, IL-2, and IFNγ in oxazolone exposed murine skin [1]. Clinical trials with sertaconazole nitrate cream 2% show efficacy in the treatment of superficial cutaneous fungal infections [2]. Sertaconazole reduces inflammation via inducing PGE2 production and the COX-2 inhibitor blocks sertaconazole from exerting its anti-inflammatory effects in a mouse model of TPA-induced ear edema [3]. 物理化学性质： CAS号：99592-39-9 常用中文名：硝酸舍他康唑常用英文名：Sertaconazole nitrate 分子式：C20H16Cl3N3O4S 分子量：500.783 密度：N/A 沸点：614.1ºC at 760mmHg 熔点：158-160° 闪点：325.2ºC 储存条件：?20°C

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公司名：上海化源世纪贸易有限公司推荐

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公司介绍：
化源网，2015 年正式成立，是专注服务全球精细化学与生物医药研发领域的专业社群电商平台。
平台严选优质品牌商家直供，以正品低价为核心优势，搭配简洁易操作的商城界面，为研发人员提供一站式采购方案，全程保障高效便捷的服务体验。

其他供应商价格：

2022-02-19 价格：￥194.9 Sertaconazole nitrate

2025-09-17 价格：￥需询单硝酸舍他康唑

2018-08-06 价格：￥需询单硝酸舍他康唑

2017-12-11 价格：￥需询单硝酸舍他康唑

2022-03-22 价格：$需询单 Sertaconazole nitrate

2021-02-06 价格：￥669.0 Sertaconazole nitrate

2018-07-31 价格：￥需询单硝酸舍他康唑

2024-01-09 价格：$需询单 Sertaconazole nitrate

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硝酸舍他康唑价格

硝酸舍他康唑

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