Piboserod Hydrochloride

产品详情：

发布时间： 2024-07-17 15:20:23

CAS号：178273-87-5

常用名： 盐酸Piboserod

价格：
￥需询单/100mg ￥需询单/250mg ￥需询单/1g

纯度： 98.0%

备货期： 10天

库存： 3

其他详情（用途，包装）：
用途： Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist.IC50 value:Target: 5-HT4 antagonistin vitro: Piboserod did not modify the basal contractions but concentration-dependently antagonized the ability of 5-HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5-HT-induced potentiations were reduced to 45.0+/-7.9 and 38.7+/-8.7%, respectively [1].in vivo: Piboserod significantly increased LVEF by 1.7% vs. placebo (CI 0.3, 3.2, P = 0.020), primarily through reduced end-systolic volume from 165 to 158 mL (P = 0.060). There was a trend for greater increase in LVEF (2.7%, CI -1.1, 6.6, P = 0.15) in a small subset of patients not on chronic beta-blocker therapy. There was no significant effect on neurohormones, quality of life, or exercise tolerance. Patients on piboserod reported more adverse events, but numbers were too small to identify specific safety issues [2]. Pretreatment with potent 5-HT4 ligands dose-dependently reduced striatal SB207145 concentration and the effective dose to achieve 50% receptor occupancy (ED50 ) values were 4.8, 2.0, 7.4, 9.9, 3.8 and 0.02 mg/kg for GR113808, piboserod, prucalopride, RS67333, TD8954 and PF04995274, respectively [3]. 物理化学性质： CAS号：178273-87-5 常用中文名：盐酸Piboserod 常用英文名：Piboserod (hydrochloride) 分子式：C22H32ClN3O2 分子量：405.96100 密度：N/A 沸点：570.3ºC at 760 mmHg 熔点：N/A 闪点：298.7ºC 储存条件：2-8℃

供应商信息：

公司名：DC Chemicals Limited 推荐

认证状态： 已认证供应商

商品数： 34961件

电话： 58447131

地址： 浦东新区金豫路100号

地区： 上海市浦东新区

联系人： Tony Cao

联系人电话： 13564518121

邮件：sales@dcchemicals.com

网址：http://www.dcchemicals.com

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年贸易额：>1000万

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公司介绍：
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.

D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.

We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.

Our credo is committed to the adoption of different products, reliable quality, competitive prices and quality service to create value for customers.

其他供应商价格：

2024-07-15 价格：需询单 Piboserod hydrochloride

查看所有价格请点击：

盐酸Piboserod价格

Piboserod Hydrochloride

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