格隆溴铵
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更新时间: 2025-10-18 16:37:46
CAS号:596-51-0
常用名:
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¥需询单/500g
¥需询单/1kg
¥需询单/25kg
¥需询单/200kg
纯度: 0.0%
备货期: 需询单
库存: 有现货
其他详情(用途,包装):
用途: Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.IC50 Value:Target: mAChR (Muscarinic acetylcholine receptor M1)in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate dissociates slowly from HASM muscarinic receptors (60% protection against [3H]-NMS binding at 30 nM) compared to ipratropium bromide [1].in vivo: Glycopyrrolate (1 mg) tablets were then administered, starting with one tablet daily the third week and increasing the daily dose by one tablet per week until a maximum of four tablets during week six and 4 days of week seven when the daily dose was reduced to two tablets for 3 days. glycopyrrolate can be given in controlled doses provided that an adequate medical assessment has been undertaken [2]. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect [3]. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children [4]. phase III study, 52.3% of glycopyrrolate oral solution recipients (aged 3-18 years; n = 137) had an mTDS response (primary endpoint); the response rate was consistently above 50% at all 4-weekly timepoints, aside from the first assessment at week 4 (40.3%). In general, glycopyrrolate oral solution was well tolerated in clinical trials. The majority of adverse events were within expectations as characteristic anticholinergic outcomes [5].Toxicity: Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD50=709 mg/kg (rat, oral). 物理化学性质: CAS号:596-51-0 常用中文名:甘罗溴铵 常用英文名:Glycopyrrolate 分子式:C19H28BrNO3 分子量:398.335 密度:N/A 沸点:N/A 熔点:193 - 194.5ºC 闪点:N/A 储存条件:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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2024-07-15 价格:需询单
2019-03-05 价格:¥5378.0
2022-11-29 价格:¥需询单
2021-02-06 价格:¥489.0
2025-09-17 价格:¥需询单
2022-02-19 价格:¥47.9
2023-11-18 价格:¥需询单
2018-02-07 价格:¥需询单
2022-05-27 价格:¥1000.0
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格隆溴铵价格为¥需询单/500g, 由格隆溴铵生产厂家盼得(上海)国际贸易有限公司提供,供应信息包括纯度,备货期/库存,供货能力等。>>电脑版:格隆溴铵_价格_生产厂家【盼得(上海)国际贸易有限公司】
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