替韦立马

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更新时间： 2024-11-14 19:02:31

CAS号：869572-92-9

常用名： Tecovirimat

价格：
￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg

纯度： 99.0%

备货期： 需询单

库存： 有现货

其他详情（用途，包装）：
用途： Tecovirimat(ST-246) is an orally bioavailable antipoxvirus compound; potent and selective active against multiple orthopoxviruses with EC50 about 10 nM.IC50 value: 10 nM [1]Target: antipoxvirusin vitro: ST-246 targets the cowpox virus V061 gene, which encodes a major envelope protein homologous to the vaccinia virus F13L gene product. The antiviral potency and selectivity of ST-246 was measured in CPE assays against a panel of DNA- and RNA-containing viruses. In these assays, the EC50 for inhibition of vaccinia virus was determined to be 0.01 μM, while the EC50 values for inhibition of unrelated viruses were >40 μM [1]. ST-246 was evaluated for activity against cowpox virus (CV), vaccinia virus (VV), and ectromelia virus (ECTV) and had an in vitro 50% effective concentration (EC50) of 0.48 microM against CV, 0.05 microM against VV, and 0.07 microM against ECTV. The selectivity indices were >208 and >2,000 for CV and VV, respectively. The in vitro antiviral activity of ST-246 was significantly greater than that of cidofovir, which had an EC50 of 41.1 microM against CV and 29.2 microM against VV, with selectivity indices of >7 and >10, respectively [2]. in vivo: Mice were treated with placebo (vehicle), ST-246 administered by oral gavage at 50 mg/kg twice a day (b.i.d.) for 14 days, or CDV administered as a single intraperitoneal (i.p.) injection at 100 mg/kg. ST-246-treated mice mounted a protective immune response to vaccinia virus infection [1]. ST-246 administered once daily by oral gavage to mice infected intranasally with CV beginning 4 h or delayed until 72 h postinoculation was highly effective when given for a 14-day duration using 100, 30, or 10 mg/kg of body weight. When 100 mg/kg of ST-246 was administered to VV-infected mice, a duration of 5 days was sufficient to significantly reduce mortality even when treatment was delayed 24 h postinoculation. Viral replication in liver, spleen, and kidney, but not lung, of CV- or VV-infected mice was reduced by ST-246 compared to levels for vehicle-treated mice [2]. 物理化学性质： CAS号：869572-92-9 常用中文名：Tecovirimat 常用英文名：Tecovirimat 分子式：C19H15F3N2O3 分子量：376.32900 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20°C，密闭，干燥

供应商信息：

公司名：盼得（上海）国际贸易有限公司推荐

认证状态： 已认证供应商

商品数： 4831件

电话： 021-60665632

地址： 上海市徐汇区中山西路1800号20楼H室

地区： 上海市徐汇区

联系人： 叶经理

联系人电话： 18019361053

邮件：1710932455@qq.com

网址：http://www.iepanda.com/

主要市场：国内、欧美、东南亚、韩国、日本等

公司介绍：
盼得（上海）国际贸易有限公司，专注于化工产品的进口和国内分销。我们为客户提供各类优质化学品，如食品添加剂、表面活性剂、催化剂和助剂、香精香料、化工原料等。

我们在国内有5个仓储基地，根据客户需求和地理位置就近存放货物，提升物流效率；我们在国内有3个生产基地用来消化我们进口的优质原料，加工成附加值更高的产品，来满足国内日益增长的需求。

团队有10多年的行业经验，货源质量稳定并提供前沿技术支持。以客户为中心，以产品为桥梁，连接全球，创造无限可能，为国内客户提高更多的供应链选项。

其他供应商价格：

2024-07-15 价格：需询单 ST246

2022-11-29 价格：￥需询单 Tecovirimat

2024-03-12 价格：￥926.9 Tecovirimat（mixture of isomers）

2021-12-23 价格：￥6034.0 [Perfemiker]Tecovirimat,98%

2024-05-31 价格：￥需询单 Tecovirimat

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Tecovirimat价格

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