水飞蓟宾

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更新时间： 2026-06-24 17:56:30

CAS号：22888-70-6

常用名： 水飞蓟宾A

价格：
￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg

纯度： 0.0%

备货期： 需询单

库存： 有现货

其他详情（用途，包装）：
用途： Silibinin, an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.IC50 value:Target: anticancerin vitro: silibinin significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines, suggesting that silibinin-induced NAG-1 up-regulation is p53-independent manner.Silibinin up-regulates early growth response-1 (EGR-1) expression [1]. silibinin induced cell death in human breast cancer cell lines MCF7 and MDA-MB-231. Silibinininduced cell death was attenuated by antioxidants, N-acetylcysteine (NAC) and Trolox, suggesting that the effect of silibinin was dependent on generation of reactive oxygen species (ROS) [2]. SIL treatment resulted in a dose- and time-dependent inhibition of HCC cell viability, SIL exhibited strong antitumor activity, as evidenced not only by reductions in tumor cell adhesion, migration, intracellular glutathione (GSH) levels and total antioxidant capability (T-AOC) but also by increases in the apoptotic index, caspase3 activity, and reactive oxygen species (ROS). SIL treatment decreased the expression of the Notch1 intracellular domain (NICD), RBP-Jκ, and Hes1 proteins, upregulated the apoptosis pathway-related protein Bax, and downregulated Bcl2, survivin, and cyclin D1. Notch1 siRNA (in vitro) or DAPT (a known Notch1 inhibitor, in vivo) further enhanced the antitumor activity of SIL, and recombinant Jagged1 protein (a known Notch ligand in vitro) attenuated the antitumor activity of SIL [3].in vivo: Topical application of silibinin at the dose of 9 mg/mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis[4]. The kidney cortex of vehicle-treated control OVE26 mice displayed greater Nox4 expression and twice as much superoxide production than cortex of silybin-treated mice. The glomeruli of control OVE26 mice displayed 35% podocyte drop out that was not present in the silybin-treated mice [5]. 物理化学性质： CAS号：22888-70-6 常用中文名：水飞蓟宾A 常用英文名：Silymarin 分子式：C25H22O10 分子量：482.436 密度：1.5±0.1 g/cm3 沸点：793.0±60.0 °C at 760 mmHg 熔点：164-174°C 闪点：274.5±26.4 °C 储存条件：−20°C

供应商信息：

公司名：盼得（上海）国际贸易有限公司推荐

认证状态： 已认证供应商

商品数： 4895件

电话： 021-60665632

地址： 上海市徐汇区中山西路1800号20楼H室

地区： 上海市徐汇区

联系人： 叶经理

联系人电话： 18019361053

邮件：1710932455@qq.com

网址：http://www.iepanda.com/

主要市场：国内、欧美、东南亚、韩国、日本等

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公司介绍：
盼得（上海）国际贸易有限公司专注于化工产品的进口与国内分销，为客户提供各类优质化学品，涵盖食品添加剂、表面活性剂、催化剂和助剂、香精香料以及多种化工原料等。
我们紧密结合客户需求以及地理位置特点，就近安排货物配送，显著提升物流配送效率，确保货物快速、准确地送达客户手中。
团队有10多年的行业经验，货源质量稳定并提供前沿技术支持。以客户为中心，以产品为桥梁，连接全球，创造无限可能，为国内客户提高更多的供应链选项。

其他供应商价格：

2024-09-29 价格：￥需询单水飞蓟宾

2022-02-19 价格：￥122.9 Silibinin

2019-03-05 价格：￥918.0 水飞蓟宾

2025-12-29 价格：￥需询单水飞蓟宾A

2024-07-15 价格：需询单水飞蓟宾

2018-05-16 价格：￥需询单水飞蓟素

2018-07-12 价格：￥280.0 水飞蓟素

2020-12-08 价格：￥1582.0 西利马灵

2018-08-01 价格：￥需询单水飞蓟提取物

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水飞蓟宾A价格

水飞蓟宾

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