马来酸氟吡汀

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更新时间： 2026-03-13 04:39:57

CAS号：75507-68-5

常用名： 马来酸氟吡汀

价格：
￥需询单/200kg

纯度： 98.0%

备货期： 需询单

库存： 现货

其他详情（用途，包装）：
用途： Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.IC50 Value: Target: Potassium channel; NMDA receptorin vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with an lC50 against steady-state responses of 182.1+/-12.1 microM. The effects of flupirtine were voltage-independent and not associated with receptor desensitization making actions within the NMDA receptor channel or at the glycine modulatory site unlikely. NMDA receptor antagonism probably has little relevance for the clinical efficacy of flupirtine as the concentrations needed were far higher than those achieved in clinical practice. However, the activation of a G-protein-regulated inwardly rectifying K+ channel was identified as an interesting molecular target site of flupirtine. In the next stage, the central nervous spectrum of action of experimental K+ channel openers (PCO) was considered. As far as they have been studied, experimental K+ channel openers display a spectrum of action comparable to that of flupirtine [1]. Therapeutic flupirtine concentrations (≤10 μM) did not affect voltage-gated Na(+) or Ca(2+) channels, inward rectifier K(+) channels, nicotinic acetylcholine receptors, glycine or ionotropic glutamate receptors. Flupirtine shifted the gating of K(V)7 K(+) channels to more negative potentials and the gating of GABA(A) receptors to lower GABA concentrations [2]. Cell exposure to flupirtine decreased the amplitude of delayed rectifier K(+) current (I(K(DR))) with a concomitant raise in current inactivation in NSC-34 neuronal cells [4].in vivo: Rats were trained to discriminate the novel analgesic flupirtine (10.0 mg/kg i.p., 10 min) from no drug under a two-choice fixed-ratio 5 shock-termination schedule. Flupirtine yielded a dose-response curve with an ED50 of 3.87 mg/kg. The opioid analgesics pentazocine, codeine and tramadol failed to produce flupirtine appropriate responding. The opioid antagonist naltrexone did not antagonize the discriminative effects of flupirtine [3]. Both morphine (ED50=0.74 mg/kg) and flupirtine (ED50=3.32 mg/kg) caused dose-related anti-hyperalgesia at doses that did not cause sedation [5]. Toxicity: Based on study-end data, hepatotoxicity was detected in 31% of patients receiving flupirtine for ≥ 6 weeks [6]. 物理化学性质： CAS号：75507-68-5 常用中文名：马来酸氟吡汀常用英文名：Flupirtine maleate 分子式：C19H21FN4O6 分子量：420.392 密度：1.35 g/cm3 沸点：434.9ºC at 760 mmHg 熔点：186-188ºC 闪点：216.8ºC 储存条件：2-8°C

供应商信息：

公司名：苏州市森菲达化工有限公司推荐

认证状态： 已认证供应商

商品数： 20000件

电话： 0512-18796480002

地址： 苏州市高新区浒墅关经济技术开发区

地区： 苏州市相城区

联系人： 程经理

联系人电话： 18796480002

邮件：13771713870@163.com

网址：http://www.senfeida.com

主要市场：国内，海外

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公司介绍：
苏州市森菲达化工有限公司，位于苏州市高新区浒墅关经济技术开发区。是由一群高分子精细化工专业人员组建而成的，专为客户提供配套化学原料。为解决客户的实质问题，我们专注于引入新产品,带入新思路，尤在 3D打印、UV光固化方面有先进的功能性原材料和强大的技术后盾。自有的合成研发团队与应用实验室，并投资入股在湖南岳阳的化工厂,长期定制**。

湖南岳阳基地**环氧活性稀释剂（缩水甘油醚），UV单体稀释剂、精细化工产品。

我们的经营理念：永续经营，创造利润，分享顾客。

服务宗旨：坚持品质**，信誉为本，用户至上之原则，以“品质、服务、诚信、服务”为理念，和广大新老客户共创。

其他供应商价格：

2022-02-19 价格：￥350.9 马来酸氟吡汀

2025-09-17 价格：￥需询单马来酸氟吡汀

2022-11-03 价格：￥4800.0 马来酸氟吡汀

2024-07-15 价格：需询单 (2-氨基-6-((4-氟苄基)氨基)吡啶-3-基)氨基甲酸乙酯马来酸盐

2017-07-11 价格：￥需询单马来酸氟吡汀

2020-04-16 价格：￥需询单马来酸氟吡汀

2021-02-06 价格：￥929.0 Flupirtine maleate

2024-04-23 价格：￥需询单马来酸氟吡汀

2018-03-22 价格：￥需询单马来酸氟吡汀

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